View Vol. 4 No. 2 (2013): Volume 4 Issue 2
Published: 2013-04-15

Original Articles

  • Comparative studies on arsenic, nickel & lead levels in ambient air repairable suspended particulate matter (p.m10) in and around Tirupati

    Prasad P.M.N. (1), Shyam Sundar E. (2), Hanuman Reddy V. (3), Chenna Krishna Reddy R. (4), Rami Reddy Y.V. (5)
    (1) Enviro-Analytical Laboratory, Department of Chemistry, S.V.University, Tirupati -517502, Andhra Pradesh, India, India,
    (2) Vimta Labs Limited, Hyderabad, Telangana, India, India,
    (3) Enviro-Analytical Laboratory, Department of Chemistry, S.V.University, Tirupati -517502, Andhra Pradesh, India, India,
    (4) Enviro-Analytical Laboratory, Department of Chemistry, S.V.University, Tirupati -517502, Andhra Pradesh, India, India,
    (5) Enviro-Analytical Laboratory, Department of Chemistry, S.V.University, Tirupati -517502, Andhra Pradesh, India, India
    DOI record not available
    118-122
    Abstract Views : 28
    Download :13
  • Assessment of quality of life of patients with epilepsy in the neurology OPD of a tertiary care University hospital

    Vanitha Rani N. (1), Nisha Alice Varughese (2), Shankar V. (3), Kannan G. (4), Thennarasu P. (5)
    (1) Department of Pharmacy Practice, Sri Ramachandra College of Pharmacy, Porur, Chennai-600 116, Tamil Nadu, India, India,
    (2) Department of Pharmacy Practice, Sri Ramachandra College of Pharmacy, Porur, Chennai-600 116, Tamil Nadu, India, India,
    (3) Department of Neurology, Sri Ramachandra Medical Center and Hospital, Sri Ramachandra University, Porur, Chennai-600 116, Tamil Nadu, India, India,
    (4) Department of Pharmacy Practice, Sri Ramachandra College of Pharmacy, Porur, Chennai-600 116, Tamil Nadu, India, India,
    (5) Department of Pharmacy Practice, Sri Ramachandra College of Pharmacy, Porur, Chennai-600 116, Tamil Nadu, India, India
    DOI record not available
    141-145
    Abstract Views : 23
    Download :15
  • Preparation and evaluation of buccal patches of losartan potassium using hydrophilic polymers

    Rajesh R.S. (1), Karthikeyan A. (2), Deepthi Swapna P.R. (3), Senthila S. (4), John Wesley I. (5)
    (1) Department of Pharmaceutics, The Dale View College of Pharmacy & Research Centre, Trivandrum-695575, Kerala, India, India,
    (2) Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Tamil Nadu-601533, India, India,
    (3) Department of Pharmaceutics, The Dale View College of Pharmacy & Research Centre, Trivandrum-695575, Kerala, India, India,
    (4) Department of Pharmaceutics, The Dale View College of Pharmacy & Research Centre, Trivandrum-695575, Kerala, India, India,
    (5) Department of Pharmaceutics, The Dale View College of Pharmacy & Research Centre, Trivandrum-695575, Kerala, India, India
    DOI record not available
    146-154
    Abstract Views : 31
    Download :12
  • Detection of extended spectrum beta lactamase in escherichia coli and Klebsiella pneumoniae isolates from clinical samples

    Shahitha S. (1), Kumaravel S. (2), Poornima K. (3)
    (1) PG and Research Department of Microbiology, Muthayammal College of Arts and Science, Rasipuram, Tamil Nadu, India, India,
    (2) PG and Research Department of Microbiology, Muthayammal College of Arts and Science, Rasipuram, Tamil Nadu, India, India,
    (3) PG and Research Department of Microbiology, Muthayammal College of Arts and Science, Rasipuram, Tamil Nadu, India, India
    DOI record not available
    155-158
    Abstract Views : 25
    Download :24
  • A novel UPLC–MS/MS method for the estimation of an immunosuppressant in human whole blood

    Anju Aji (1), Sarita Karthikeyan (2), Sarabjit Singh (3), Shivanand Puthli (4)
    (1) J.J.T. University, Jhunjhunu, Rajasthan, India / Panacea Biotec Ltd, 72/3 TTC Industrial Area, Mahape, Navi Mumbai, Maharashtra 400710, India, India,
    (2) J.J.T. University, Jhunjhunu, Rajasthan, India / Panacea Biotec Ltd, 72/3 TTC Industrial Area, Mahape, Navi Mumbai, Maharashtra 400710, India, India,
    (3) Panacea Biotec Ltd, 72/3 TTC Industrial Area, Mahape, Navi Mumbai, Maharashtra 400710, India, India,
    (4) Panacea Biotec Ltd, 72/3 TTC Industrial Area, Mahape, Navi Mumbai, Maharashtra 400710, India, India
    DOI record not available
    159-164
    Abstract Views : 18
    Download :17
  • Studies on the detection of genetic variation of commercially cultivated Mushroom species using RAPD markers

    Prasad M.P. (1), Rekha Sethi (2)
    (1) Sangenomics Research Labs, Bangalore- 560071, Karnataka, India, India,
    (2) Department of Microbiology, Jain University, Bangalore, Karnataka, India, India
    DOI record not available
    165-170
    Abstract Views : 19
    Download :16
  • Prevalence and antimicrobial susceptibility pattern of ESBL producing gram negative rods causing nosocomial infection

    Umer Syed (1), Shakirullah (2), Aziz Ullah (3), Baharullah (4), Hamid Iqbal (5), Abdul Wahab (6), Ali Rehman (7)
    (1) Department of Microbiology, Quaid-E-Azam University, Islamabad, Pakistan, Pakistan,
    (2) Department of Microbiology, Abasyn University Peshawar, Khyber Pakhtunkhwa, Pakistan, Pakistan,
    (3) Department of Microbiology, Kohat University of Science & Technology Kohat, Khyber Pakhtunkhwa, Pakistan , Pakistan,
    (4) Department of Microbiology, Kohat University of Science & Technology Kohat, Khyber Pakhtunkhwa, Pakistan , Pakistan,
    (5) Department of Microbiology, Kohat University of Science & Technology Kohat, Khyber Pakhtunkhwa, Pakistan , Pakistan,
    (6) Department of Pharmacy, Kohat University of Science & Technology Kohat, Khyber Pakhtunkhwa, Pakistan , Pakistan,
    (7) Department of Chemistry, Kohat University of Science & Technology Kohat, Khyber Pakhtunkhwa, Pakistan, Pakistan
    DOI record not available
    171-176
    Abstract Views : 26
    Download :15
  • Antibacterial activity of a few medicinal plants against Xanthomonas campestris pv. campestris

    Nidhi Didwania (1), Deepti Sadana (2), Trivedi P. C. (3)
    (1) Department of Biotechnology, Manav Rachna International University, Faridabad, Haryana, India, India,
    (2) Department of Biotechnology, Manav Rachna International University, Faridabad, Haryana, India, India,
    (3) Vice Chancellor, Deen Dayal Upadhyay University, Gorakhpur, Uttar Pradesh, India, India
    DOI record not available
    177-182
    Abstract Views : 21
    Download :21
  • Spectrophotometric determination of pramipexole di-hydrochloride in bulk and tablet dosage form

    Pawar D.S. (1), Dole M.N. (2), Sawant S.D. (3)
    (1) Department of Pharmaceutical Chemistry, Smt. Kashibai Navale College of Pharmacy, Kondhwa (Bk), Pune-411048, Maharashtra, India, India,
    (2) Department of Pharmaceutical Chemistry, Smt. Kashibai Navale College of Pharmacy, Kondhwa (Bk), Pune-411048, Maharashtra, India, India,
    (3) Department of Pharmaceutical Chemistry, Smt. Kashibai Navale College of Pharmacy, Kondhwa (Bk), Pune-411048, Maharashtra, India, India
    DOI record not available
    183-186
    Abstract Views : 29
    Download :13
  • Over expression of p53 and its role as early biomarker in carcinoma of the uterine cervix

    Krishnan Baskaran (1), Santha Karunanithi (2), Inmozhi Sivakamasundari (3), Junior Sundresh N. (4), Thamaraiselvi B. (5), Swaruparani S. (6)
    (1) Division of Biochemistry, Rajah Muthiah Medical College & Hospital, Annamalai University, Annamalainagar- 608 002, Tamil Nadu, India, India,
    (2) Division of Biochemistry, Rajah Muthiah Medical College & Hospital, Annamalai University, Annamalainagar- 608 002, Tamil Nadu, India, India,
    (3) Division of Biochemistry, Rajah Muthiah Medical College & Hospital, Annamalai University, Annamalainagar- 608 002, Tamil Nadu, India, India,
    (4) Division of Surgery, Rajah Muthiah Medical College & Hospital, Annamalai University, Annamalainagar- 608 002, Tamil Nadu, India, India,
    (5) Department of Gynecology and Obstetrics, Thanjavur Medical College, Thanjavur-613 004, Tamil Nadu, India, India,
    (6) Department of Gynecology and Obstetrics, Thanjavur Medical College, Thanjavur-613 004, Tamil Nadu, India, India
    DOI record not available
    198-202
    Abstract Views : 42
  • In vitro anti-inflammatory activity of hydroalcoholic extract of Asparagus racemosus roots

    Suchita Mittal (1), Praveen K Dixit (2), Rupesh K Gautam (3), Gupta M.M. (4)
    (1) Department of Pharmacology, Jaipur College of Pharmacy, Jaipur, Rajasthan-302022, India, India,
    (2) Department of Pharmacology, Jaipur College of Pharmacy, Jaipur, Rajasthan-302022, India, India,
    (3) Department of Pharmacology, Jaipur College of Pharmacy, Jaipur, Rajasthan-302022, India, India,
    (4) Department of Pharmaceutics, Jaipur College of Pharmacy, Jaipur, Rajasthan-302022, India, India
    DOI record not available
    203-206
    Abstract Views : 56
    Download :18
  • Secretory Expression of recombinant human Interferon-alpha2b in methilotropic yeast Pichia pastoris

    Ratih Asmana Ningrum (1), Adi Santoso (2), Neng Herawati (3)
    (1) Molecular Biology Department, Research Center for Biotechnology, Indonesian Institute of Science (LIPI), Cibinong, Bogor 16911, Indonesia, Indonesia,
    (2) Molecular Biology Department, Research Center for Biotechnology, Indonesian Institute of Science (LIPI), Cibinong, Bogor 16911, Indonesia, Indonesia,
    (3) Molecular Biology Department, Research Center for Biotechnology, Indonesian Institute of Science (LIPI), Cibinong, Bogor 16911, Indonesia, Indonesia
    DOI record not available
    207-210
    Abstract Views : 17
    Download :13
  • A new spectrophotometric method for the determination of Solifenacin in pure form and in pharmaceutical formulations

    Alia Afra S. (1), Rameeja S. (2), Madhavi R. (3), Venkataramanamma C. (4), Divya G. (5), Srilakshmi Y. (6), Gobinath M. (7), Saravanan D. (8)
    (1) Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh 524346, India, India,
    (2) Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh 524346, India, India,
    (3) Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh 524346, India, India,
    (4) Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh 524346, India, India,
    (5) Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh 524346, India, India,
    (6) Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh 524346, India, India,
    (7) Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh 524346, India, India,
    (8) Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh 524346, India, India
    DOI record not available
    221-225
    Abstract Views : 43
    Download :15
  • Formulation of liquisolid tablets of candesartan cilexetil

    Abdul Hasan Sathali A. (1), Deepa C. (2)
    (1) Department of Pharmaceutics, College of Pharmacy, Madurai Medical College, Madurai-625 020, Tamil Nadu, India, India,
    (2) Department of Pharmaceutics, College of Pharmacy, Madurai Medical College, Madurai-625 020, Tamil Nadu, India, India
    DOI record not available
    238-249
    Abstract Views : 28
    Download :36
  • Formulation and evaluation of floating in situ gel of Nizatidine

    Jadhav S.L. (1), Banerjee S.K. (2)
    (1) Department of Pharmaceutical Sciences, Karpagam University, Coimbatore, Tamil Nadu - 641021, India, India,
    (2) Department of Pharmaceutical Sciences, Karpagam University, Coimbatore, Tamil Nadu - 641021, India, India
    DOI record not available
    250-255
    Abstract Views : 76
    Download :28
  • Comparison of curcumin level in fresh and decoction of dried Curcuma xanthorrhiza Roxb. rhizome

    Ramdan Panigoro (1), Samsudin Surialaga (2), Diah Dhianawaty D. (3)
    (1) Biochemistry Department Faculty of Medicine of Universitas Padjadjaran, Bandung, Indonesia, Indonesia,
    (2) Biochemistry Department Faculty of Medicine of Universitas Padjadjaran, Bandung, Indonesia, Indonesia,
    (3) Biochemistry Department Faculty of Medicine of Universitas Padjadjaran, Bandung, Indonesia, Indonesia
    DOI record not available
    256-259
    Abstract Views : 18
    Download :21
  • Development and evaluation of herbal gel formulation of Magnifera indica linn extract

    Gaikwad D.D. (1), Banerjee S.K. (2)
    (1) Department of Pharmaceutical Sciences, Karpagam University, Coimbatore - 641 021, Tamil Nadu, India, India,
    (2) Department of Pharmaceutical Sciences, Karpagam University, Coimbatore - 641 021, Tamil Nadu, India, India
    DOI record not available
    260-265
    Abstract Views : 61
    Download :33
  • Antioxidant activity of the waste water of boiled Zea mays (sweet corn) on the cob

    Diah Dhianawaty D. (1), Ramdan Panigoro (2)
    (1) Biochemistry Department, Faculty of Medicine of Universitas Padjadjaran, Bandung, Indonesia, Indonesia,
    (2) Biochemistry Department, Faculty of Medicine of Universitas Padjadjaran, Bandung, Indonesia, Indonesia
    DOI record not available
    266-269
    Abstract Views : 21
    Download :16
  • Pharmacognostical and phyto-physicochemical investigation of Mangifera indica Linn.

    Gaikwad D.D. (1), Banerjee S.K. (2)
    (1) Department of Pharmaceutical Sciences, Karpagam University, Coimbatore - 641 021, Tamil Nadu, India, India,
    (2) Department of Pharmaceutical Sciences, Karpagam University, Coimbatore - 641 021, Tamil Nadu, India, India
    DOI record not available
    270-275
    Abstract Views : 36
    Download :31
  • Formulation and evaluation of floating mucoadhesive beads of Nizatidine

    Jadhav S L (1), Banrjee S K (2)
    (1) Department of Pharmaceutical Sciences, Karpagam University, Coimbatore-641 021, Tamil Nadu, India, India,
    (2) Department of Pharmaceutics, Vishal Institute of Pharmaceutical Education and Research, Ale, Pune, Maharashtra, India, India
    DOI record not available
    276-282
    Abstract Views : 22
    Download :28
  • Standardization of Rasayana churna – A classical ayurvedic formulation

    Hardik Soni (1), Surendra Bhatt (2), Biswajyoti Patgiri (3)
    (1) Vasu Research Centre (A Division of Vasu Healthcare Pvt. Ltd.), 896/A, GIDC, Makarpura, Vadodara – 390 010, Gujarat, India, India,
    (2) Vasu Research Centre (A Division of Vasu Healthcare Pvt. Ltd.), 896/A, GIDC, Makarpura, Vadodara – 390 010, Gujarat, India, India,
    (3) Department of Rasashastra & Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda (IPGT&RA), Gujarat Ayurved University, Jamnagar – 361 008, Gujarat, India, India
    DOI record not available
    283-289
    Abstract Views : 46
    Download :25
  • Application of Planar chromatography for the simultaneous determination of Metformin Hydrochloride and Glimepiride in combined dosage form

    Dhobale Shankar Maruti (1), Subir Kumar Banerjee (2)
    (1) Department of Pharmaceutical Sciences, Karpagam University, Coimbatore, Tamil Nadu, India, India,
    (2) Department of Pharmaceutical Sciences, Karpagam University, Coimbatore, Tamil Nadu, India, India
    DOI record not available
    290-294
    Abstract Views : 28
    Download :18
  • Studies on antibacterial, antioxidant, larvicidal, pesticidal activities and phytochemistry of Leonotis nepetifolia (Linn) R. Br.

    Udaya Prakash N.K. (1), Bhuvaneswari S. (2), Balamurugan A. (3), Vaishnavi S. (4), Sunisha Sugunan (5), Sindhu Meena (6), Chandran M. (7), Sekar Babu H. (8)
    (1) Research and Development, Veltech Dr. RR Dr. SR Technical University, Avadi-Alamadhi Road, Avadi, Chennai 600062, India, India,
    (2) Research and Development, MARINA LABS, 40, Anna Nedum Pathai, Choolaimedu, Chennai 600094, India, India,
    (3) Research and Development, MARINA LABS, 40, Anna Nedum Pathai, Choolaimedu, Chennai 600094, India, India,
    (4) Research and Development, MARINA LABS, 40, Anna Nedum Pathai, Choolaimedu, Chennai 600094, India, India,
    (5) Research and Development, MARINA LABS, 40, Anna Nedum Pathai, Choolaimedu, Chennai 600094, India, India,
    (6) Research and Development, MARINA LABS, 40, Anna Nedum Pathai, Choolaimedu, Chennai 600094, India, India,
    (7) Research and Development, Veltech Dr. RR Dr. SR Technical University, Avadi-Alamadhi Road, Avadi, Chennai 600062, India, India,
    (8) Research and Development, Veltech Dr. RR Dr. SR Technical University, Avadi-Alamadhi Road, Avadi, Chennai 600062, India, India
    DOI record not available
    303-309
    Abstract Views : 42
    Download :21
  • Development and validation of HPTLC method for estimation of acyclovir in formulations

    Dhobale Shankar Maruti (1), Subir Kumar Banerjee (2)
    (1) Department of Pharmaceutical Sciences, Karpagam University, Coimbatore, Tamil Nadu, India, India,
    (2) Department of Pharmaceutical Sciences, Karpagam University, Coimbatore, Tamil Nadu, India, India
    DOI record not available
    310-315
    Abstract Views : 52
    Download :48
  • Formulation and evaluation of Ebastine mouth dissolving tablets by molecular dispersion technique

    Raja Sridhar Rao P. (1), Chandrasekara Rao G. (2)
    (1) Department of Pharmaceutics, S.R. College of Pharmacy, Warangal-506371, Andhra Pradesh, India , India,
    (2) Department of Pharmaceutics, Yalamarty College of Pharmacy, Anandapuram, Visakhapatnam-531163, Andhra Pradesh, India, India
    DOI record not available
    316-320
    Abstract Views : 48
    Download :41
  • Development and evaluation of sustained release matrix transdermal patches of Nano carvedilol

    Ashok Kumar J. (1), Gopal V. (2)
    (1) Faculty of Pharmacy, PRIST University, Thanjavur-614904, Tamil Nadu, India, India,
    (2) Mother Theresa Institute of Health Sciences, Pondicherry, India, India
    DOI record not available
    321-327
    Abstract Views : 16
    Download :21

Review Article

  • Mechanisms involved in hepatoprotection of different herbal products: A Review

    Anil Kumar (1), Nishant Rai (2), Navin Kumar (3), Pankaj Gautam (4), Kumar J.S. (5)
    (1) Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, India, India,
    (2) Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, India, India,
    (3) Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, India, India,
    (4) Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, India, India,
    (5) Department of Biotechnology, SBS PG Institute of Biomedical Sciences and Research, Balawala, Dehradun, Uttarakhand, India, India
    DOI record not available
    112-117
    Abstract Views : 38
    Download :24
  • A review on identification strategy of phyto constituents present in herbal plants

    Charishma Yalavarthi (1), Thiruvengadarajan V. S. (2)
    (1) Department of Pharmaceutical Analysis and Quality Assurance, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India, India,
    (2) Department of Pharmaceutical Analysis and Quality Assurance, Annamacharya College of Pharmacy, Rajampet, Andhra Pradesh, India, India
    DOI record not available
    123-140
    Abstract Views : 54
    Download :30
  • Liposomes as novel drug delivery system: A comprehensive review

    Nagasamy Venkatesh Dhandapani (1), Anup Thapa (2), Goti Sandip (3), Ayush Shrestha (4), Niroj Shrestha (5), Rajan Sharma Bhattarai (6)
    (1) Department of Pharmaceutics, JSS College of Pharmacy, Udhagamandalam – 643001, Tamil Nadu, India, India,
    (2) Department of Pharmaceutical Analysis, JSS College of Pharmacy, Udhagamandalam – 643001, Tamil Nadu, India, India,
    (3) Department of Pharmaceutical Analysis, JSS College of Pharmacy, Udhagamandalam – 643001, Tamil Nadu, India, India,
    (4) Department of Pharmacology, JSS College of Pharmacy, Udhagamandalam – 643001, Tamil Nadu, India, India,
    (5) Department of Pharmacology, JSS College of Pharmacy, Udhagamandalam – 643001, Tamil Nadu, India, India,
    (6) Formulation, Research and Development, Dr. Reddy’s Laboratories Private Limited, Hyderabad, India, India
    DOI record not available
    187-193
    Abstract Views : 142
    Download :33
  • Curcumin nanoforms promise better therapeutic values

    Heni Rachmawati (1)
    (1) Research Group of Pharmaceutics, School of Pharmacy, Bandung Institute of Technology, Ganesha 10, Bandung 40132, Indonesia, Indonesia
    DOI record not available
    211-220
    Abstract Views : 17
    Download :13
  • A review on process validation as an essential process

    Bharat Parashar (1), Rohit Gupta (2), Gaurav Khurana (3)
    (1) Department of Pharmaceutics, Manav Bharti University, Solan, Himachal Pradesh, India, India,
    (2) Department of Pharmaceutics, Manav Bharti University, Solan, Himachal Pradesh, India, India,
    (3) Department of Pharmaceutics, Manav Bharti University, Solan, Himachal Pradesh, India, India
    DOI record not available
    226-229
    Abstract Views : 49
    Download :20
  • The road of generic medicines towards improving the accessibility of essential medicines

    Bora Lichanda (1), Mi Luo (2), Bikui Zhang (3)
    (1) Department of Pharmaceutics, Third Xiangya Hospital, Central South University, Changsha, 410013, China / School of Pharmaceutical Science, Central South University, Changsha 410013, China, China,
    (2) Department of Pharmaceutics, Third Xiangya Hospital, Central South University, Changsha, 410013, China / School of Pharmaceutical Science, Central South University, Changsha 410013, China, China,
    (3) Department of Pharmaceutics, Third Xiangya Hospital, Central South University, Changsha, 410013, China, China
    DOI record not available
    230-237
    Abstract Views : 16
    Download :7
  • Anti-inflammatory agents of herbal origin: An overview

    Praveen K Dixit (1), Suchita Mittal (2)
    (1) Jaipur College of Pharmacy, Jaipur, Rajasthan – 302022, India, India,
    (2) Jaipur College of Pharmacy, Jaipur, Rajasthan – 302022, India, India
    DOI record not available
    295-302
    Abstract Views : 50
    Download :18

Short Communication

  • Diet and colorectal cancer: knowledge assessment among Malaysian university students

    Abdul Rahman M.F. Nahas (1), Azmi Sarriff (2), Saad Othman (3)
    (1) School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800 Malaysia, Malaysia,
    (2) School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800 Malaysia, Malaysia,
    (3) School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800 Malaysia, Malaysia
    DOI record not available
    194-197
    Abstract Views : 14
    Download :12