Formulation and evaluation of floating mucoadhesive beads of Nizatidine

Abstract

An objective of the present study was to develop alginate/hydroxypropyl methylcellulose (HPMC)/chitosan based floating-mucoadhesive beads of Nizatidine to provide prolonged contact time of drug to treat gastric disorders. Floating-mucoadhesive beads were prepared and characterized for invivo performance in rabits. Beads were prepared by ionic gelation technique where calcium chloride used as gelating agent. Prepared beads were evaluated extensively for particle size, drug entrapment; swelling and surface morphology by using scanning electron microscopy, in vitro mucoadhesion using rat stomach mucosal membrane and invitro drug release studies were carried out. Alginate-HPMC-chitosan beads may be suitable floating-mucoadhesive drug delivery system for delivering Nizatidine to treat gastric disorders.