Development and evaluation of sustained release matrix transdermal patches of Nano carvedilol

Abstract

Transdermal drug delivery system of nano carvedilol has been formulated by solvent casting method. Nano sized carvedilol was prepared by high pressure homogenization technique and morphology of nano particles confirmed by scanning electron microscopy. Sustained release nano carvedilol matrix patches were prepared by using hydroxyl propyl methyl cellulose (HPMC) and poly vinyl pyrrolidone (PVP). Physicochemical parameters like thickness uniformity, folding endurance, elongation break, weight variation, drug content uniformity, percentage moisture content, percentage moisture uptake, water vapor transmission rate (WVTR) were evaluated. On the basis of in vitro drug release studies (12 hours) and ex vivo permeation performance, formulation code CT2 was found to be better than other formulation and it was selected as the optimized formulation. In vitro kinetic studies results followed higuchi (r²=0.9948), and the mechanism of release was diffusion. The optimized patch was found to be stable at 40^oC ± 2^oC and 75 ± 5 % RH for six month with respect to their physicochemical parameters and drug content.