International Journal of Research in Pharmaceutical Sciences https://ijrps.com/home <p align="justify"><strong>International Journal of Research in Pharmaceutical Sciences (IJRPS)</strong> ISSN: 0975-7538 sponsored by JK Welfare &amp; Pharmascope Foundation is established in the year 2009 with people from various avenues of the pharmacy profession. IJRPS is completely devoted to publications related to Pharmaceuticals and Health Sciences. IJRPS will be published quarterly. The journal publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical and Health Sciences.</p> en-US ijrpseditor@gmail.com (Editor) ijrpseditor@gmail.com (Managing Editor) Thu, 02 Jan 2025 00:00:00 +0000 OJS 3.3.0.10 http://blogs.law.harvard.edu/tech/rss 60 A study on the evaluation of the anatomical skills learning methodology reviews given by the paramedic students - a cross-sectional study https://ijrps.com/home/article/view/4735 The anatomical based foundation for both the medic and paramedic students becomes essential to progress in their carrier. Anatomical practical skills become important to have thorough knowledge of the structures involved in theoretical and practical part of the anatomy for the paramedic students.The aim of the study is to evaluate the skill learning methodology reviews given by the paramedic students. The study will be conducted in the Department of Anatomy, SRIHER after getting a approval from the Institutional Ethical Committee. 100 numbers of paramedical students were assessed for the period of six months from Aug 2023 to Jan 2024. Two Google forms will be given, and effectiveness of the anatomical skills reviews were collected. The forms will be given both in virtual mode and in person mode and ask them to submit in classroom itself. Data collected in the google form, will be analysed, interpreted and the result will be obtained. Results will be obtained from the paramedical students based on the results analysed the finalised forms will be evaluated. Anatomical learning skills for the anatomy students becomes essential as the topic was very vague and facing challenges during Vivas. In this regard, this study becomes very important for the Paramedic students to give a better performance to learn the subject. Dr. Kavitha, Dr. Srimathi Copyright (c) 2025 International Journal of Research in Pharmaceutical Sciences https://creativecommons.org/licenses/by-nc-nd/4.0 https://ijrps.com/home/article/view/4735 Mon, 06 Jan 2025 00:00:00 +0000 Geno protective efficacy of D-Pinitol isolated from aerial parts of Glycine max L. (Merr.) on Doxorubicin-mediated genotoxicity assessed through in vivo comet assay https://ijrps.com/home/article/view/4733 The goal of this investigation was to determine whether D-pinitol could protect against doxorubicin-mediated genotoxicity using the in vivo Comet test. Ten groups of Swiss albino mice (n = 6) were formed. Group I (Control) received a 0.9% NaCl treatment for fifteen days. Group II (Positive control) received doxorubicin (DOX) at 5 mg/kg intraperitoneally (i.p.) for three days on the first, eighth, and fifteenth days. Mice were administered D-pinitol (D-P) at various concentrations (100 mg/kg, 200 mg/kg, 300 mg/kg, and 400 mg/kg p.o.) for 15 days, categorized as Groups III, IV, V, and VI based on increasing D-P dosages. Group VII received DOX followed by D-P 100 mg/kg, while Group VIII received D-P 200 mg/kg before DOX. Group IX received D-P 300 mg/kg before DOX, and Group X received D-P 400 mg/kg before DOX. The in vivo Comet assay assessed DNA damage after collecting EDTA blood samples (50 µl) from all experimental and control groups. A highly significant increase in DNA damage (P<0.001) was observed in the DOX-only group. D-P showed no significant effect on DNA damage compared to the Control group. However, the group receiving D-P before DOX demonstrated a significant (P<0.001) dose-dependent reduction in DNA damage compared to the positive control. Sudha M, Vinciya T, Parameswari P, Sanjukta Sainath Singh, Noorul Alam I Copyright (c) 2025 International Journal of Research in Pharmaceutical Sciences https://creativecommons.org/licenses/by-nc-nd/4.0 https://ijrps.com/home/article/view/4733 Fri, 03 Jan 2025 00:00:00 +0000 Protective effect of venotonic formula Hemoronil tablet on croton oil prompted hemorrhoid model in wistar albino rats https://ijrps.com/home/article/view/4732 Hemorrhoids are among the most common and prevalent anorectal disorders, affecting an estimated 4.4% of the general population worldwide. Traditional herbal medicine has held a prominent role in the treatment of hemorrhoids since ancient times. Currently, phlebotonics are extensively utilized to manage a range of conditions, including hemorrhoids and chronic venous insufficiency. The present study evaluated the oral acute toxicity and efficacy of phlebotonics fortified with vitamins (Hemoronil Tablet) in alleviating hemorrhoidal disorders induced by croton oil in Wistar albino rats.Two series of experiments were conducted: the first evaluated the acute oral toxicity effect of Hemoronil in an experimental model, and the second assessed its protective effect in animals with induced hemorrhoids. The acute oral toxicity analysis revealed no clinical signs or mortalities when administered once orally at doses up to 2000 mg/kg. Croton oil treatment significantly increased the recto-anal coefficient (p<0.0001) in the positive control group compared to normal control animals. Administration of Hemoronil tablet (400 mg/kg) (p<0.0001) caused a significant decline in the recto-anal coefficient, and the cytoarchitecture of the recto-anal portion showed marked protection against histological damage, appearing significantly similar to normal tissue. Treatment with Hemoronil tablet also resulted in a reduction in vasodilation and inflammatory cell infiltration. Additionally, treatment with Hemoronil tablet at 200 mg/kg also led to a mild yet significant improvement in the restoration of the damaged histoarchitecture of recto-anal tissue.The combination of phlebotonics fortified with vitamin C in the Hemoronil tablet is non-toxic and exhibits beneficial effects in ameliorating hemorrhoids through its antioxidant, anti-inflammatory, and hemostatic properties. Soumya Krishnan, Linto John, Layana Joshy Copyright (c) 2025 International Journal of Research in Pharmaceutical Sciences https://creativecommons.org/licenses/by-nc-nd/4.0 https://ijrps.com/home/article/view/4732 Thu, 02 Jan 2025 00:00:00 +0000 Simvastatin nanoparticles prepared by planetary ball milling: physicochemical evaluation and stability studies https://ijrps.com/home/article/view/4738 Simvastatin (SIM) is a Class II drug with a reported bioavailability of only 5%, primarily due to its low solubility and extensive metabolism. Nanoparticle formulation offers a potential solution to these challenges. In this study, SIM nanoparticles were prepared using the wet milling method, a top-down approach. The effects of different ball sizes and stabilizers on particle size, zeta potential, dissolution parameters, and stability were evaluated. SIM tablets incorporating the best-stabilized nanoparticles were also formulated and assessed.The results demonstrated that reducing SIM to the nanoscale significantly enhanced its dissolution rate. The nanoparticles exhibited sizes ranging from 123 ± 3.8 to 733.5 ± 23.1 nm, with a zeta potential between -11 and -66 mV. Stability studies confirmed that SIM nanoparticles stabilized with 5% HPMC and 5% PL-F127 met USP impurity requirements (<2%). However, the lowest drug degradation was observed in SIM nanoparticles stabilized with 5% HPMC.In vitro release studies using 0.5 mm milling balls and 5% HPMC demonstrated an improved dissolution profile, with 26.8%, 21.85%, and 18.81% drug release at zero, three, and six months, respectively, compared to untreated SIM (14.3%, 11.0%, and 10.33%). SIM tablets with nanoparticles achieved significantly higher dissolution (25.23 ± 0.41%) than Zocor® (16.34 ± 1.09%). These findings highlight HPMC as a promising stabilizer for SIM nanoparticles. Doaa H. Alshora, Bander M. AlMalki, Mohamed A. Ibrahim, Fars K. Alanazi, Ehab M. Elzayat Copyright (c) 2025 International Journal of Research in Pharmaceutical Sciences https://creativecommons.org/licenses/by-nc-nd/4.0 https://ijrps.com/home/article/view/4738 Fri, 17 Jan 2025 00:00:00 +0000 A comprehensive review of the siddha herbo-mineral formulation: vaazhai pazha jayaneer (VPJ) https://ijrps.com/home/article/view/4736 Background: Siddha medicine, a traditional system of healing, is acclaimed for its unique therapeutic formulations that incorporate minerals, metallic preparations, and medicinal plants. Vaazhai Pazha Jayaneer (VPJ), a herbo-mineral formulation, is prepared using Rasathaali Vaazhai Pazham (Musa acuminata colla), Karchunnaambu (limestone), and the ashes of dried banana bark. VPJ is traditionally used to treat urinary tract infections and as a base for high-potency Siddha medicines. Objective: To validate the traditional claims regarding VPJ by exploring its composition, traditional applications, and pharmacological properties through scientific analysis. Materials and Methods: The formulation was selected from the Siddha literature Anuboga Vaithiya Navaneetham. Raw materials were procured and authenticated by experts. VPJ was prepared using standard methods, and the pharmacological activities of its ingredients were documented. Results: The ingredients of VPJ exhibit diverse therapeutic properties, including anti-diabetic, antioxidant, anti-ulcer, anti-hypertensive, anti-inflammatory, and antimicrobial activities. These pharmacological actions support its traditional uses in Siddha medicine. Conclusion: VPJ, as a herbo-mineral formulation, holds significant therapeutic potential. Scientific validation reinforces its efficacy, encouraging further preclinical and clinical studies to explore its full medicinal applications. Shanmugapriyan Pazhani, Suresh Ramasamy Copyright (c) 2025 International Journal of Research in Pharmaceutical Sciences https://creativecommons.org/licenses/by-nc-nd/4.0 https://ijrps.com/home/article/view/4736 Mon, 13 Jan 2025 00:00:00 +0000 A short narrative on article processing charges (apcs) for open accessed journals (oa) in scientific studies https://ijrps.com/home/article/view/4734 Many open-access (OA) publishers impose fees on authors in exchange for unrestricted online availability of their papers. This work reviews the literature on article processing charges (APCs) published since 2000. Although some OA journals allow free publication, most OA papers are published by commercial publishers that impose article-level charges (APCs). To cover these costs, authors rely on a combination of personal funds, library budgets, and research grants.APCs have raised two primary concerns: their impact on journal quality and the inability of authors with limited funding to publish their research. Waivers have not effectively resolved the underlying issue over time. Studies in the literature reveal limited expansion of waiver utilization, unintended negative effects on co-author networks, and concerns about the eligibility criteria for waivers. Recent bibliometric research indicates that APC-charging publications influence citations similarly to journals with other revenue streams.This short narrative review examines whether APCs are essential for OA publishing. Sonam Bhutia Copyright (c) 2025 International Journal of Research in Pharmaceutical Sciences https://creativecommons.org/licenses/by-nc-nd/4.0 https://ijrps.com/home/article/view/4734 Sat, 04 Jan 2025 00:00:00 +0000