International Journal of Research in Pharmaceutical Sciences

Protective effect of venotonic formula Hemoronil tablet on croton oil prompted hemorrhoid model in wistar albino rats

Soumya Krishnan, Linto John, Layana Joshy — Thu, 02 Jan 2025 00:00:00 +0000

Hemorrhoids are among the most common and prevalent anorectal disorders, affecting an estimated 4.4% of the general population worldwide. Traditional herbal medicine has held a prominent role in the treatment of hemorrhoids since ancient times. Currently, phlebotonics are extensively utilized to manage a range of conditions, including hemorrhoids and chronic venous insufficiency. The present study evaluated the oral acute toxicity and efficacy of phlebotonics fortified with vitamins (Hemoronil Tablet) in alleviating hemorrhoidal disorders induced by croton oil in Wistar albino rats.Two series of experiments were conducted: the first evaluated the acute oral toxicity effect of Hemoronil in an experimental model, and the second assessed its protective effect in animals with induced hemorrhoids. The acute oral toxicity analysis revealed no clinical signs or mortalities when administered once orally at doses up to 2000 mg/kg. Croton oil treatment significantly increased the recto-anal coefficient (p<0.0001) in the positive control group compared to normal control animals. Administration of Hemoronil tablet (400 mg/kg) (p<0.0001) caused a significant decline in the recto-anal coefficient, and the cytoarchitecture of the recto-anal portion showed marked protection against histological damage, appearing significantly similar to normal tissue. Treatment with Hemoronil tablet also resulted in a reduction in vasodilation and inflammatory cell infiltration. Additionally, treatment with Hemoronil tablet at 200 mg/kg also led to a mild yet significant improvement in the restoration of the damaged histoarchitecture of recto-anal tissue.The combination of phlebotonics fortified with vitamin C in the Hemoronil tablet is non-toxic and exhibits beneficial effects in ameliorating hemorrhoids through its antioxidant, anti-inflammatory, and hemostatic properties.

Geno protective efficacy of D-Pinitol isolated from aerial parts of Glycine max L. (Merr.) on Doxorubicin-mediated genotoxicity assessed through in vivo comet assay

Sudha M, Vinciya T, Parameswari P, Sanjukta Sainath Singh, Noorul Alam I — Fri, 03 Jan 2025 00:00:00 +0000

The goal of this investigation was to determine whether D-pinitol could protect against doxorubicin-mediated genotoxicity using the in vivo Comet test. Ten groups of Swiss albino mice (n = 6) were formed. Group I (Control) received a 0.9% NaCl treatment for fifteen days. Group II (Positive control) received doxorubicin (DOX) at 5 mg/kg intraperitoneally (i.p.) for three days on the first, eighth, and fifteenth days. Mice were administered D-pinitol (D-P) at various concentrations (100 mg/kg, 200 mg/kg, 300 mg/kg, and 400 mg/kg p.o.) for 15 days, categorized as Groups III, IV, V, and VI based on increasing D-P dosages. Group VII received DOX followed by D-P 100 mg/kg, while Group VIII received D-P 200 mg/kg before DOX. Group IX received D-P 300 mg/kg before DOX, and Group X received D-P 400 mg/kg before DOX. The in vivo Comet assay assessed DNA damage after collecting EDTA blood samples (50 µl) from all experimental and control groups. A highly significant increase in DNA damage (P<0.001) was observed in the DOX-only group. D-P showed no significant effect on DNA damage compared to the Control group. However, the group receiving D-P before DOX demonstrated a significant (P<0.001) dose-dependent reduction in DNA damage compared to the positive control.

A short narrative on article processing charges (apcs) for open accessed journals (oa) in scientific studies

Sonam Bhutia — Sat, 04 Jan 2025 00:00:00 +0000

Many open-access (OA) publishers impose fees on authors in exchange for unrestricted online availability of their papers. This work reviews the literature on article processing charges (APCs) published since 2000. Although some OA journals allow free publication, most OA papers are published by commercial publishers that impose article-level charges (APCs). To cover these costs, authors rely on a combination of personal funds, library budgets, and research grants.APCs have raised two primary concerns: their impact on journal quality and the inability of authors with limited funding to publish their research. Waivers have not effectively resolved the underlying issue over time. Studies in the literature reveal limited expansion of waiver utilization, unintended negative effects on co-author networks, and concerns about the eligibility criteria for waivers. Recent bibliometric research indicates that APC-charging publications influence citations similarly to journals with other revenue streams.This short narrative review examines whether APCs are essential for OA publishing.