Formulation and evaluation of Trospium chloride Microspheres for sustained drug delivery

Abstract

The objective of the present study was to prepare and evaluate microspheres for the sustained release of Trospium Chloride by using various ratio of 1.5%w/v chitosan polymer, 2.5% w/v chitosan polymer, 3.5%w/v chitosan polymer. It is used to treat the Urge urinary incontinence and overactive bladders are common conditions often associated with profound impairment of the health and quality of life of the patient. It ma inly acts as the M3 receptor antagonist that is present on sphincter muscle which is present at the urinary bladder opening. Trospium Chloride loaded Chitosan microspheres were prepared by a solvent evaporation method. The resultant microspheres were evaluated for average particle size, drug entrapment, In vitro drug release. FTIR, DSC and SEM were used to investigate the physical state of the drug in the microspheres. The mean particle size of the microspheres was influenced by varying drug Polymer ratio while drug loading was dependent on drug : polymer ratio. The entrapment efficiency was 98.23%. The release of drug from the microspheres extended upto 8 to 12hrs. The results of FTIR indicated the stable character of Trospium Chloride loaded Chitosan microspheres and also absence of drug polymer interaction. The Trospium Chloride loaded Chitosan microspheres prepared under optimized conditions showed good sustained release characteristics & were stable under the conditions studied.