Anti-Hyperlipidaemic Activity of Ethanol Extract of Whole Plant of Corallocarpus Epigaeus on Wistar rats

Chandra Sekhar K.B.; Devanna N.; Sandhya Rani N.V.N.A.; Sreenivasa Krishna O.; Gowri Sree M.; Mallikarjun G.

Chandra Sekhar K.B. ⁽¹⁾ , Devanna N. ⁽²⁾ , Sandhya Rani N.V.N.A. ⁽³⁾ , Sreenivasa Krishna O. ⁽⁴⁾ , Gowri Sree M. ⁽⁵⁾ , Mallikarjun G. ⁽⁶⁾

(1) Oil Technological Research Institute, JNTU, Anantapur, Andhra Pradesh, India, India ,

(2) JNTU College of Engineering, Kalikiri, Andhra Pradesh, India, India ,

(3) Oil Technological Research Institute, JNTU, Anantapur, Andhra Pradesh, India, India ,

(4) Oil Technological Research Institute, JNTU, Anantapur, Andhra Pradesh, India, India ,

(5) Oil Technological Research Institute, JNTU, Anantapur, Andhra Pradesh, India, India ,

(6) Oil Technological Research Institute, JNTU, Anantapur, Andhra Pradesh, India, India

Issue
Vol. 6 No. 1 (2015): Volume 6 Issue 1

Keywords:

Anti-hyperlipidemic, Lipid profile, Triton, High fat, Corallocarpus epigaeus, Simvastatin

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Abstract

The anti hyperlipidemic activity of Corallocarpus epigaeus (family Cucurbitaceae) whole plant extract was studied in triton and high fat diet (HFD) induced models in albino rats. The present study was designed to investigate the antihyperlipidemic activity of EECE extract in Triton X-100 and High fat diet induced hyperlipidemic rats. Treatment with plant extract (200 and 400 mg/kg, p.o body weight) was able to significantly decrease the levels of TC, TG and LDL. Also the extract was found to cause a significant increase in the HDL levels. Therefore it can be concluded that EECE extract is able to effectively suppress Triton and High fat diet induced Hyperlipidaemia in rats, suggesting the potential protective role in coronary heart disease. The hypolipidemic activity of whole plant extract of Corallocarpus epigaeus was compared with a standard drug simvastatin (20 mg/kg p.o body weight), a known lipid- lowering agent in both models. This result is considered as important for the treatment of Hyperlipidaemia induced atherosclerosis and apparently validates the folk medicinal use of hyperlipidemic patients in India.