Formulation and evaluation of antineoplastic drug loaded nanoparticles incorporated in sucralfate suspension as drug delivery system

Abstract

The main objective of the present work was to formulation and evaluatation of 5-Fluorouracil drug loaded nano- particles incorporated in sucralfate Suspension as drug delivery system. 5 -Fluorouracil nanoparticles prepared by Nanoprecipitation method using sodium alginate as   cross linking agent. Prepared nanoparticles were evaluated for drug entrapment efficiency, particle size, FTIR, DSC, TEM analysis and drug release studies. Based on above studies  FN12 was selected as optimize formulation. Sucralfate suspension were prepared in order to select the best suspending agent concentration based on the evaluation test FS6 compositions were selected for incorporation of Nanoparticle . 5-Fluorouracil loaded nanoparticles incorporated in sucralfate suspension were prepared and characterized for various evaluation tests and FNS12 was optimized formulation to be selected. Comparative pharmacokinetic studies were carried for 5-Fluorouracil drug loaded Sucralfate Suspension and 5 -Fluorouracil loaded nanoparticles incorporated in sucralfate suspension and evaluated for various pharmacokinetic parameters. The results indicate the increase in T1/2 and MRT in the in nanoparticles incorporated in Sucralfate suspension and sustain the drug release compare to Sucralfate Suspension. Histological examination revealed that there is a severe bleeding due to continuous use of 5-Fluorouracil Suspension observed within one week thus 5-Fluorouracil loaded nanoparticles incorporated in Sucralfate suspension (FNS12) was proved to be safe and effective for long term use.