Formulation development and evaluation of floating drug delivery of Anti-diabetic drug

Abstract

Polymer concentration and gas generating agents were effect on the floating drug release from floating tablets. To utilize the dissolution data and gain insight into the drug release mechanism from polymer floating tablet. The objective of the present research was to enhance sustained release floating tablets of Glibenclamide by wet granulation method by using synthetic and natural polymers like tamarindus indica seed powder extract and HPMC K4, ethyl cellulose as floating agent, microcrystalline cellulose as super disintegrate, filler, talc, magnesium stearate as glidant and lubricant. The active pharmaceutical ingredient, excipient mixtures are subjected to pre-formulation studies such as Fourier transform infra-red spectroscopy and differential scanning colorometry shown that there was  no interaction between drug and polymers.  The floating tablets are subjected to physicochemical, in-vitro drug release and kinetic studies. The prepared formula tions of physicochemical properties were found within the limits. The optimized formulation of drug release was extended for a period of 8 hr. The release kinetics of formulated drug follows first order models.