Preparation and Evaluation of Topical Polyherbal Emulgel Formulation for its Wound Healing Potential

Abstract

Physical harm that causes the skin to break or open up are known as wounds. For the repair of broken anatomical continuity and compromised functional status of the skin, proper wound healing is crucial. It is the end result of a coordinated response to harm from various cell types. The contraction and closure of the wound as well as the restoration of a functional barrier are the consequences of the intricate, multifactorial process known as wound healing. Due to its lower risk of side effects and lower cost, traditional medicine has seen increased use in recent years. When more than one herb is included in a single formulation, this is known as a polyherbal formulation, and the potency of the single herbal medications is increased. The purpose of the current study was to assess an emulgel made of developed polyherbal ingredients against wound healing. The current study aims to assess the created formulation’s ability to treat burns and excision wounds in terms of wound healing potential. Excise and burn wounds largely recovered. A group of rats given the medication showed signs of re-epithelialization of cells in newly formed tissue. At the healing site, there was also evidence of fibroblastic and vascular procreation. Without the presence of any microorganisms, the formulation effectively increases the rate of epithelialization and collagen viability across the wound region. According to the findings, the produced formulation (EG1) was superior to the extract in terms of effectiveness for wound healing.