Evaluation of the Impact of the Ayurvedic Formulation ”Amruthotharam” on Obesity-Related Diabetic and Hepatic Disorders

Abstract

Diabetes mellitus (DM) is a non-communicable disease that affects people  all over the world and is defined by ongoing hyperglycemia. Sulfonylureas, biguanides, -glucosidase inhibitors, and non-sulfonylurea secretagogues are a few oral hypoglycemic medications that are frequently recommended by doctors for managing diabetes. Oral hypoglycemic medication use causes noticeable negative effects, and there is currently no permanent viable treatment for DM recovery. Complementary and alternative therapies must be used to lower the incidence of disease until better medical methods are discovered. The search for an efficient medication, either by itself or in combination, to treat diabetes continues to be fruitless. This might have a viable replacement in the shape of herbal preparations, which are widely employed in conventional medical systems. In order to determine the impact of Amruthotharam kashaya prepared using a traditional method for a four-week treatment period on blood glucose levels as well as other biochemical parameters like total cholesterol, LDL, HDL, and VLDL in HFD-alloxan-induced diabetic rats, the present study was designed. Significant weight loss was also seen with diabetes management, and this was partially reversed after formulation administration. The formulation significantly decreased increased levels of a few particular biochemical markers and avoided other hyperglycemia-related complications. These findings offer scientific support for the anti-diabetic usage of a conventional formulation and imply that the administration of the formulation to rats can be used safely by humans because it lowers the levels of several biochemical factors that contribute to diabetes.