Apigenin protects 7, 12-dimethylbenz(a)anthracene–induced chromosomal abnormalities and DNA damage in the bone marrow cells of golden Syrian hamsters

Simon Silvan (1) , Shanmugam Manoharan (2) , Nagarethinam Baskaran (3) , Arjun Kumar Singh (4)
(1) Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India, India ,
(2) Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India, India ,
(3) Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India, India ,
(4) Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India, India

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Vol. 4 No. 3 (2013): Volume 4 Issue 3
Keywords:
    Apigenin, Chromosomal aberrations, DNA damage, DMBA, MnPCEs
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Abstract

The present study has investigated the protective effect of apigenin on 7, 12-dimethylbenz(a)anthracene (DMBA)- induced chromosomal abnormalities and DNA damage in the bone marrow cells of golden Syrian hamsters. The protective effect of apigenin was examined by analyzing the frequency of micronucleated polychromatic erythro- cytes (MnPCEs), chromosomal aberrations and DNA damage in hamsters treated with DMBA. We noticed an increase in MnPCEs frequency, chromosomal aberrations and DNA damage in hamsters treated with DMBA alone. Oral pretreatment of apigenin for 5 days to DMBA-treated hamsters significantly decreased the frequency of MnPCEs, chromosomal aberrations and DNA damage. The present study thus suggests that apigenin has the ability to prevent 7, 12-dimethylbenz(a)anthracene–induced chromosomal abnormalities and DNA damage in the bone marrow cells of golden Syrian hamsters.

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Authors

Simon Silvan
Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India
Shanmugam Manoharan
Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India
sakshiman@rediffmail.com (Primary Contact)
Nagarethinam Baskaran
Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India
Arjun Kumar Singh
Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India
Simon Silvan, Shanmugam Manoharan, Nagarethinam Baskaran, & Arjun Kumar Singh. (2013). Apigenin protects 7, 12-dimethylbenz(a)anthracene–induced chromosomal abnormalities and DNA damage in the bone marrow cells of golden Syrian hamsters. International Journal of Research in Pharmaceutical Sciences, 4(3), 445–452. Retrieved from https://ijrps.com/home/article/view/3740
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