Development and evaluation of haloperidol orally disintegrating tablets using novel co–processed superdisintegrants

Abstract

Orally disintegrating tablets are gaining popularity over conventional tablets due to their convenience in administration and suitability for patients. In the present work, fast dissolving tablets of Haloperidol were prepared using novel co-processed superdisintegrants consisting of crospovidone and primogel in the different ratios (1:1, 1:2 & 1:3) by direct compression technique. Evaluated for the pre-compression parameters such as bulk density, compressibility, angle of repose etc. The prepared batches of tablets were evaluated for hardness, weight variation, friability, drug content, disintegration time and in-vitro dissolution profile and found satisfactory. Among all, the formulation CP1 containing 4%w/w superdisintegrant (1:1 mixture of crospovidone and primogel) was considered to be best formulation, which release up to 99.21% in 12 min. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.