Formulation and evaluation of mouth dissolving tablets of losartan potassium by direct compression techniques

Suhas M. Kakade; Vinodh S. Mannur; Ketan B. Ramani; Ayaz A. Dhada; Chirag V. Naval; Avinash Bhagwat

Suhas M. Kakade ⁽¹⁾ , Vinodh S. Mannur ⁽²⁾ , Ketan B. Ramani ⁽³⁾ , Ayaz A. Dhada ⁽⁴⁾ , Chirag V. Naval ⁽⁵⁾ , Avinash Bhagwat ⁽⁶⁾

(1) Department of Pharmaceutics, J. N. Medical College, KLE University, Belgaum – 590010, Karnataka, India, India ,

(2) Department of Pharmaceutics, J. N. Medical College, KLE University, Belgaum – 590010, Karnataka, India, India ,

(3) Department of Pharmaceutics, J. N. Medical College, KLE University, Belgaum – 590010, Karnataka, India, India ,

(4) Department of Pharmaceutics, J. N. Medical College, KLE University, Belgaum – 590010, Karnataka, India, India ,

(5) Department of Pharmaceutics, J. N. Medical College, KLE University, Belgaum – 590010, Karnataka, India, India ,

(6) Department of Pharmaceutics, J. N. Medical College, KLE University, Belgaum – 590010, Karnataka, India, India

Issue
Vol. 1 No. 3 (2010): Volume 1 Issue 3

Keywords:

Losartan potassium, Mouth dissolving tablet, superdisintegrants, Dissolution rate

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Abstract

In the present work, mouth dissolving tablets of losartan potassium were design with a view to enhance the patient compliance and provide a quick onset of action. Losartan potassium is an angiotensin receptor antagonist, used in the management of hypertension. It has low bioavailability due to its first pass metabolism. Hence the main objective of the study was to formulate mouth dissolving tablets of losartan potassium to achieve a better dissolution rate and further improving the bioavailability of the drug. Mouth dissolving tablets prepared by direct compression and using super disintegrants like Polyplasdone XL 10, Croscarmellose sodium and Explotab in different concentration and evaluated for the pre-compression parameters such as bulk density, compressibility, angle of repose etc. The prepared batches of tablets were evaluated for hardness, weight variation, friability, drug content, disintegration time and in-vitro dissolution profile and found satisfactory. Among all, the formulation F3 containing 5%w/w superdisintegrant Polyplasdone XL 10 was considered to be best formulation, which release up to 99.26% in 12 min.