Cytotoxicity study of Shalmali extract on human endometrial stromal cells

Abstract

Various herbs are extensively used by the customary medical practitioners for curing numerous diseases in their day-to-day practice. Shalmali (Bombax ceiba) is a recognized plant used in the customary system for the management of various diseases. It has an extensive range of pharmacological and medicinal applications. In the current study, efforts have been made to summarize diverse aspects of scientific studies on the role of Shalmali extract on uterine bleeding. Therefore the cytotoxicity study of Shalmali extract was performed on endometrial cell lines using MTT assay.  The absorbance by human endometrial stromal cells (T HESCs cells) was noted and the percentage of cell viability of T HESCs with varying treatment concentration of Shalmali extract was calculated in contrast to the standard placebo. The Shalmali extract showed cytotoxicity effect on T HESCs cells and the IC₅₀  of the extract is 110µg/ml. To conclude that Shalmali extract showed a positive correlation was found to exist between the presence of antioxidant compounds and cytotoxicity against cells. Our results concluded that Shalmali extract could be used for the treatment of uterine bleeding.