Phytochemical Screening, Invitro antidiabetic activity of Muntingia calabura leaves extract on alpha-amylase and alpha-glucosidase enzymes

Abstract

Muntingia calabura is a medicinal plant broadly used in conventional therapeutic preparation of many pharmacological activities. In the present study, the Invitro antidiabetic property of Muntingia calabura leaves extracts was analyzed by using standard methods. An in vitro anti-diabetic study was done by inhibition of α-amylase and α - glucosidase enzymes. The phytochemical screening of Muntingia Calabura leaves revealed that the extract is rich in the secondary metabolites such as alkaloids, polyphenols and tannins. The in vitro antidiabetic capability of extracts such as Petroleum ether, Chloroform, Methanol and aqueous through α- amylase enzyme and alpha-glucosidase enzyme inhibition studies. The results of the present study concluded that the methanolic extract of Muntingia calabura  exhibits 80% in α-amylase and 60% in alpha-glucosidase activity while compared to acarbose. The phytochemistry study portrays the antidiabetic activity of Muntingia calabura  is due to the presence of polyphenols