Assessment of Nephroprotective Potential of Ethanolic Extract Premna Tomentosa (Ept) in Alcohol Toxicity in Male Albino Rats

Gomathi Priyadharsini T (1) , Kavimani M (2) , Sathiya Narayana Murthy S (3) , Prabhu K (4) , Arudyuti Chowdhury (5)
(1) Research Scholar, Bharath University, Department of Anatomy, Vivekananda Dental College for Women, Tiruchengode, Tamil Nadu, India, India ,
(2) Department of Anatomy, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India, India ,
(3) Research Scholar, Bharath University, Department of Anatomy, Vivekananda Dental College for Women, Tiruchengode, Tamil Nadu, India, India ,
(4) Department of Anatomy, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India, India ,
(5) Marwari Hospital, Guwahati, Assam 781001, India, India

Abstract

The nephroprotective prospective of Premna tomentosa extract against Alcohol induced nephrotoxicity in rats was investigated in the present study. The characterization of ethanol extract of Premna tomentosa (EPT) was performed using standard phytochemical analysis. Male albino wistar rats 36 in numbers were divided into 6 groups including control, negative control, positive control and various doses of EPT Treated groups; Nephrotoxicity was induced by alcohol (1ml/100gm b.wt) in animals. Rats intoxicated with Alcohol were fed with 500, 750 mg/kg dose of EPT and Liv 52 (1ml/100gm b.wt) for 60 days. Results show that EPT (500mg/kg b.wt) had a significant effect against alcohol induced nephrotoxicity in rats than EPT (750mg/kg b.wt) in blood parameters and consonantly good histopathological changes in kidney. The deleterious histopathological alterations in kidney associated with glomerular and tubular changes in alcohol intoxicated rats was evident. This result shows Premna tomentosa may be used as supplementary drug for alcoholics.

Full text article

Generated from XML file

Authors

Gomathi Priyadharsini T
dr.gomathi1985@gmail.com (Primary Contact)
Kavimani M
Sathiya Narayana Murthy S
Prabhu K
Arudyuti Chowdhury
Gomathi Priyadharsini T, Kavimani M, Sathiya Narayana Murthy S, Prabhu K, & Arudyuti Chowdhury. (2020). Assessment of Nephroprotective Potential of Ethanolic Extract Premna Tomentosa (Ept) in Alcohol Toxicity in Male Albino Rats. International Journal of Research in Pharmaceutical Sciences, 11((SPL 4), 3099–3103. Retrieved from https://ijrps.com/home/article/view/2820

Article Details

Most read articles by the same author(s)

No Related Submission Found