Formulation and evaluation of pioglitazone hydrochloride pellets

Abstract

The aim of the present study was to formulate and evaluate Pioglitazone hydrochloride pellets. The Pioglitazone hydrochloride immediate and controlled release pellets were prepared by solution/suspension layering technique by using croscarmellose in IR layer and three different polymers such as Ethyl cellulose, Eudragit L100, Xanthan gum as rate controlling polymers in four different ratios like 1:0.5,1:1, 1:1.5 and 1:2 to achieve desired drug release in CR layer. Evaluation was performed according to the pharmacopoeia standards including drug excipient compatibility, percentage yield, particle size distribution, drug content analysis and in-vitro drug release study. The best results were shown in F11 Pioglitzone and Eudragit L100 in1:1.5 ratios. A broad variety of drug release pattern could be achieved by variation of polymer ratios which was optimized to match the target release profile. In comparision of in-vitro release studies for all developed controlled release formulations, F11 relelases 97.50% of drug at the end of 12^th hour and was considered as best formulation.