Chemopreventive potential of chrysin in 7, 12-dimethylbenz(a)anthracene induced skin carcinogenesis in Swiss albino mice

Murugaraj Manoj Prabhakar; Shanmugam Manoharan; Nagarethinam Baskaran; Ramachandran Srinivasan; Sekar Karthikeyan; Shamsul Afaq Wani

Murugaraj Manoj Prabhakar ⁽¹⁾ , Shanmugam Manoharan ⁽²⁾ , Nagarethinam Baskaran ⁽³⁾ , Ramachandran Srinivasan ⁽⁴⁾ , Sekar Karthikeyan ⁽⁵⁾ , Shamsul Afaq Wani ⁽⁶⁾

(1) Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar – 608 002, Tamil Nadu, India, India ,

(2) Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar – 608 002, Tamil Nadu, India, India ,

(3) Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar – 608 002, Tamil Nadu, India, India ,

(4) Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar – 608 002, Tamil Nadu, India, India ,

(5) Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar – 608 002, Tamil Nadu, India, India ,

(6) Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar – 608 002, Tamil Nadu, India, India

Issue
Vol. 3 No. 1 (2012): Volume 3 Issue 1

Keywords:

Chemoprevention, DMBA, Skin cancer, Chrysin

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Abstract

Chrysin (5,7-dihydroxy flavone) possesses diverse pharmacological effects including anticancer potential. Aim of the present investigation was to assess the chemopreventive potential of chrysin in 7, 12- dimethylbenz(a)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice. Skin tumors in mice were developed by painting with DMBA two times a week for 8 weeks. Hundred percent tumors was noticed in mice treated with DMBA alone after 14 weeks. Though oral administration of chrysin at a dose of 250 mg/kg bw to mice treated with DMBA significantly (86.6%) prevented tumor formation, severe hyperplasia, hyperkeratosis and dysplasia was noticed. The present results suggest that chrysin might have delayed rather than inhibiting the tumor formation during DMBA-induced skin carcinogenesis.