Phytochemical compounds and pharmacological activities of lemon (Citrus limon L.) – Update Review
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Citrus, lemon, traditional uses, phytochemical compounds, pharmacological activities
Abstract
The lemon plant (Citrus limon L.) is a species from the Rutaceae family that spread from Southeast Asia and spread to all countries in the world. Lemon has been used traditionally since ancient times to treat various diseases and has been tested for various pharmacological activities. The literature review was carried out to study the phytochemical compounds and pharmacological activities of lemon plants. The literature compiled by a minimum of 50 scientific articles using search engines such as Science Direct, Pubmed, and Google Scholar, published for a maximum of the last 10 years, includes a minimum of 20 articles in the last 2 years, has a DOI, and the quality of the journal index is reviewed using Scimago. Lemon is very rich in phytochemical compounds, including flavanones such as hesperidin, eriocytrin, naringin, narirutin, didymin; flavones such as apigenin, luteolin, and diosmin; flavonols such as routine, quercetin, mirisetin, isositrol, limositrol, and limositrin; terpenoids such as limonene, limonoids, and carotenoids. Various kinds of in vivo and in vitro studies provide results of various pharmacological activities such as antioxidants, anticancer, neuroprotective, antimicrobial, antidiabetic, anti-inflammatory, antihyperlipidemic, antiurolithiasis, and antiplasmodial. It is necessary to develop further research on the pharmacological activity of lemon plants in the future.
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References
Agyare, C., Spiegler, V., Asase, A., Scholz, M., Hempel, G., Hensel, A. 2018. An ethnopharmacological survey of medicinal plants traditionally used for cancer treatment in the Ashanti region, Ghana. Journal of Ethnopharmacology, 212:137–152.
Akiyama, S., ichi Katsumata, S., Suzuki, K., Ishimi., Wu, J., Uehara, M. 2009. Dietary Hesperidin Exerts Hypoglycemic and Hypolipidemic Effects in Streptozotocin-Induced Marginal Type 1 Diabetic Rats. Journal of Clinical Biochemistry and Nutrition, 46(1):87–92.
Al-Qudah, T.S., Zahra, U., Rehman, R., Majeed, M.I., Sadique, S., Nisar, S., Tahtamouni, R.W. 2018. Lemon as a source of functional and medicinal ingredient: A review. International Journal of Chemical and Biomedical Sciences, 14:55–61.
Ali, M.Y., Zaib, S., Rahman, M.M., Jannat, S., Iqbal, J., Park, S.K., Chang, M.S. 2019. Didymin, a dietary citrus flavonoid exhibits anti-diabetic complications and promotes glucose uptake through the activation of PI3K/Akt signaling pathway in insulin resistant HepG2 cells. Chemico Biological Interactions, 305:180–194.
Alu’datt, M.H., Rababah, T., Alhamad, M.N., Al-Mahasneh, M.A., Ereifej, K., Al-Karaki, G., Al-Duais, M., Andrade, J.E., Tranchant, C.C., Kubow, S., Ghozlan, K.A. 2017. Profiles of free and bound phenolics extracted from Citrus fruits and their roles in biological systems: content, and antioxidant, antidiabetic and anti-hypertensive properties. Food & Function, 8(9):3187–3197.
Amorim, J.L., Simas, D.L.R., Pinheiro, M.M.G., Moreno, D.S.A., Alviano, C.S., da Silva, A.J.R., Fernandes, P. D. 2016. Anti-Inflammatory Properties and Chemical Characterization of the Essential Oils of Four Citrus Species. PLOS ONE, 11(4): e0153643–e0153643.
Antunes, M.S., Goes, A.T., Boeira, S.P., Prigol, M., Jesse, C.R. 2014. Protective effect of hesperidin in a model of Parkinson’s disease induced by 6-hydroxydopamine in aged mice. Nutrition, 30(11- 12):1415–1422.
Arul, D., Subramanian, P. 2013. Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine induced hepatocarcinogenesis in rats. Biochemical and Biophysical Research Communications, 434(2):203–209.
Ashraf, H., Butt, M.S., Iqbal, M.J., Suleria, H.A. R. 2017. Citrus peel extract and powder attenuate hypercholesterolemia and hyperglycemia using rodent experimental modelling. Asian Pacific Journal of Tropical Biomedicine, 7(10):870–880.
Ballistreri, G., Fabroni, S., Romeo, F.V., Timpanaro, N., Amenta, M., Rapisarda, P. 2019. Anthocyanins and Other Polyphenols in Citrus Genus: Biosynthesis, Chemical Profile, and Biological Activity. Polyphenols in Plants, pages 191–215.
Barreca, D., Gattuso, G., Bellocco, E., Calderaro, A., Trombetta, D., Smeriglio, A., Laganà, G., Daglia, M., Meneghini, S., Nabavi, S.M. 2017. Flavanones: Citrus phytochemical with health-promoting properties. BioFactors, 43(4):495–506.
Casquete, R., Castro, S.M., Martín, A., Ruiz-Moyano, S., Saraiva, J.A., Córdoba, M.G., Teixeira, P. 2015. Evaluation of the effect of high pressure on total phenolic content, antioxidant and antimicrobial activity of citrus peels. Innovative Food Science & Emerging Technologies, 31:37–44.
Chaturvedi, D., Suhane, R. R. N. S. 2016. Basketful Benefit of Citrus Limon. International Research Journal of Pharmacy, 7(6):1–4.
Chukwuma, C.I., Matsabisa, M.G., Ibrahim, M.A., Erukainure, O.L., Chabalala, M.H., Islam, M.S. 2019. Medicinal plants with concomitant anti diabetic and anti-hypertensive effects as potential sources of dual-acting therapies against diabetes and hypertension: A review. Journal of Ethnopharmacology, 235:329–360.
Chukwuma, C.I., Mopuri, R., Nagiah, S., Chuturgoon, A. A., Islam, M.S. 2018. Erythritol reduces small intestinal glucose absorption, increases muscle glucose uptake, improves glucose metabolic enzymes activities and increases expression of Glut-4 and IRS-1 in type 2 diabetic rats. European Journal of Nutrition, 57(7):2431–2444.
Cirmi, S., Ferlazzo, N., Lombardo, G., Maugeri, A., Calapai, G., Gangemi, S., Navarra, M. 2016. Chemo preventive Agents and Inhibitors of Cancer Hall- marks: May Citrus Offer New Perspectives? Nutrients, 8(11):698–698.
Dasari, S., Ganjayi, M.S., Yellanurkonda, P., Basha, S., Meriga, B. 2018. Role of glutathione S-transferases in detoxification of a polycyclic aromatic hydrocarbon, methylcholanthrene. Chemico Biological Interactions, 294:81–90.
Erukainure, O.L., Chukwuma, C.I., Sanni, O., Matsabisa, M.G., Islam, M.S. 2019. Histochemistry, phenolic content, antioxidant, and anti-diabetic activities of Vernonia amygdalina leaf extract. Journal of Food Biochemistry, 43(2):e12737.
Farzaei, F., Morovati, M.R., Farjadmand, F., Farzaei, M.H. 2017. A Mechanistic Review on Medicinal Plants Used for Diabetes Mellitus in Traditional Persian Medicine. Journal of Evidence-Based Complementary & Alternative Medicine, 22(4):944– 955.
Fernandes, A.A.H., Novelli, E.L.B., Okoshi, K., Okoshi, M.P., Muzio, B.P.D., Guimarães, J.F.C., Junior, A.F. 2010. Influence of rutin treatment on biochemical alterations in experimental diabetes. Biomedicine & Pharmacotherapy, 64(3):214–219.
Gandhi, G.R., Vasconcelos, A.B.S., Wu, D.-T., Li, H.-B., Antony, P. J., Li, H., Geng, F., Gurgel, R.Q., Narain, N., Gan, R.-Y. 2020. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies. Nutrients, 12(10):2907– 2907.
Gao, S., Hu, G., Li, D., Sun, M., Mou, D. 2020. Anti-hyperlipidemia effect of sea buckthorn fruit oil extract through the AMPK and Akt signaling pathway in hamsters. Journal of Functional Foods, 66:103837–103837.
Ghanem, N., Mihoubi, D., Kechaou, N., Mihoubi, N.B. 2012. Microwave dehydration of three citrus peel cultivars: Effect on water and oil retention capacities, color, shrinkage and total phenols content. Industrial Crops and Products, 40:167–177.
González-Molina, E., Domínguez-Perles, R., Moreno, D.A., García-Viguera, C. 2010. Natural bioactive compounds of Citrus limon for food and health. Journal of Pharmaceutical and Biomedical Analysis, 51(2):327–345.
Guimarães, R., Barros, L., Barreira, J.C., Sousa, M.J., Carvalho, A.M., Ferreira, I.C. 2010. Targeting excessive free radicals with peels and juices of citrus fruits: Grapefruit, lemon, lime and orange. Food and Chemical Toxicology, 48(1):99–106.
Gülçin, İ. 2012. Antioxidant activity of food constituents: an overview. Archives of Toxicology, 86(3):345–391.
Hajialyani, M., Farzaei, M.H., Echeverría, J., Nabavi, S., Uriarte, E., Sobarzo-Sánchez, E. 2019. Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence. Molecules, 24(3):648–648.
Hwang, S.-L., Shih, P.-H., Yen, G.-C. 2012. Neuroprotective Effects of Citrus Flavonoids. Journal of Agricultural and Food Chemistry, 60(4):877–885.
Jing, L., Zhang, Y., Fan, S., Gu, M., Guan, Y., Lu, X., Huang, C., Zhou, Z. 2013. Preventive and ameliorating effects of citrus d-limonene on dyslipidemia and hyperglycemia in mice with high-fat diet-induced obesity. European Journal of Pharmacology, 715(1-3):46–55.
Key, T.J. 2011. Fruit and vegetables and cancer risk. British Journal of Cancer, 104(1):6–11.
Klimek-Szczykutowicz, Szopa, Ekiert 2020. Citrus limon (Lemon) Phenomenon-A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food and Cosmetics Industries, and Biotechnological Studies. Plants, 9(1):119–119.
Ledesma-Escobar, C.A., Priego-Capote, F., De Castro, M.D.L. 2019. Relevance and Analysis of Citrus Flavonoids. Polyphenols in Plants, pages 133–150.
Mahmood, S., Ranjha, M.M.A.N., Shahzad, J.K., Jaangla, K.T., Bin, M.A., Mustafa, S. 2019. A Critical Review on Nutritional and Medicinal Importance of Lemon. Acta Scientific Agriculture, 3:95–97.
Makni, M., Jemai, R., Kriaa, W., Chtourou, Y., Fetoui, H. 2018. Citrus limon from Tunisia: Phytochemical and Physicochemical Properties and Biological Activities. BioMed Research International, pages 1–10.
Malakul, W., Pengnet, S., Kumchoom, C., Tunsophon, S. 2018. Naringin ameliorates endothelial dysfunction in fructose-fed rats. Experimental and therapeutic medicine, 15(3):3140–3146.
Miyake, Y., Hiramitsu, M. 2011. Isolation and extraction of antimicrobial substances against oral bacteria from lemon peel. Journal of Food Science and Technology, 48(5):635–639.
Mohanapriya, M., Ramaswamy, L., Rajendran, R. 2013. Health and medicinal properties of lemon (Citrus limonum). International Journal of Ayurvedic and Herbal Medicine, 3(1):1095–1100.
Mondal, S., Bandyopadhyay, S., Ghosh, M.K., Mukhopadhyay, S., Roy, S., Mandal, C. 2012. Natural Products: Promising Resources for Cancer Drug Discovery. Anti-Cancer Agents in Medicinal Chemistry, 12(1):49–75.
Olszowy, M. 2019. What is responsible for antioxidant properties of polyphenolic compounds from plants? Plant Physiology and Biochemistry, 144:135–143.
Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., Bitto, A. 2017. Oxidative Stress: Harms and Benefits for Human Health. Oxidative Medicine and Cellular Longevity, pages 1–13.
Rafiq, S., Kaul, R., Sofi, S. A., Bashir, N., Nazir, F., Nayik, A. 2018. Citrus peel as a source of functional ingredient: A review. Journal of the Saudi Society of Agricultural Sciences, 17(4):351–358.
Rahman, A., Siddiqui, S., Jakhar, R., Kang, S. 2015. Growth Inhibition of Various Human Cancer Cell Lines by Imperatorin and Limonin from Poncirus Trifoliata Rafin. Seeds. Anti-Cancer Agents in Medicinal Chemistry, 15(2):236–241.
Raimondo, S., Saieva, L., Cristaldi, M., Monteleone, F., Fontana, S., Alessandro, R. 2018. Label-free quantitative proteomic profiling of colon cancer cells identifies acetyl-CoA carboxylase alpha as antitumor target of Citrus limon-derived nanovesicles. Journal of Proteomics, 173:1–11.
Raspo, M.A., Vignola, M.B., Andreatta, A.E., Juliani, R. 2020. Antioxidant and antimicrobial activities of citrus essential oils from Argentina and the United States. Food Bioscience, 36:100651– 100651.
Rauf, A., Uddin, G., Ali, J. 2014. Phytochemical analysis and radical scavenging profile of juices of Citrus sinensis, Citrus anrantifolia and Citrus limonum. Organic and Medicinal Chemistry Letters, 4(1):5–5.
Ruiz, L., Ruiz, L., Maco, M., Cobos, M., Gutierrez-Choquevilca, A.-L., Roumy, V. 2011. Plants used by native Amazonian groups from the Nanay River (Peru) for the treatment of malaria. Journal of Ethnopharmacology, 133(2):917–921.
Shi, Y. S., Zhang, Y., Li, H.T., Wu, C.H., El-Seedi, H.R., Ye, W. K., Wang, Z.W., Li, C.B., Zhang, X.F., Kai, G.Y. 2020. Limonoids from Citrus: Chemistry, anti-tumor potential and other bioactivities. Journal of Functional Foods, 75:104213.
Shimizu, S., Miyamoto, S., Fujii, G., Nakanishi, R., Onuma, W., Ozaki, Y., Fujimoto, K., Yano, T., Mutoh, M. 2015. Suppression of intestinal carcinogenesis in Apc mutant mice by limonin. Journal of Clinical Biochemistry and Nutrition, 57(1):39–43.
Singh, B., Singh, J.P., Kaur, A., Singh, N. 2020. Phenolic composition, antioxidant potential and health benefits of citrus peel. Food Research International, 132:109114.
Soković, M., Glamočlija, J., Marin, P.D., Brkić, D., van Griensven, L.J.L.D. 2010. Antibacterial Effects of the Essential Oils of Commonly Consumed Medicinal Herbs Using an In Vitro Model. Molecules, 15(11):7532–7546.
Souza, L.C., de Gomes, M.G., Goes, A.T., Fabbro, L.D., Filho, C.B., Boeira, S.P., Jesse, C.R. 2013. Evidence for the involvement of the serotonergic 5-HT1A receptors in the antidepressant-like effect caused by hesperidin in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 40:103–109.
Sridharan, B., Mehra, Y., Ganesh, R.N., Viswanathan, P. 2016. Regulation of urinary crystal inhibiting proteins and inflammatory genes by lemon peel extract and formulated citrus bioflavonoids on ethylene glycol induced urolithic rats. Food and Chemical Toxicology, 94:75–84.
Tejada, S., Pinya, S., Martorell, M., Capó, X., Tur, J.A., Pons, A., Sureda, A. 2019. Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus. Current Medicinal Chemistry, 25(37):4929–4945.
Yi, L., Ma, S., Ren, D. 2017. Phytochemistry and bioactivity of Citrus flavonoids: a focus on antioxidant, anti-inflammatory, anticancer and cardiovascular protection activities. Phytochemistry Reviews, 16(3):479–511.
Yoon, J.S., Yang, H., Kim, S.H., Sung, S.H., Kim, Y.C. 2010. Limonoids from Dictamnus Dacrycarpus Protect Against Glutamate-induced Toxicity in Primary Cultured Rat Cortical Cells. Journal of Molecular Neuroscience, 42(1):9–16.
Zou, Z., Xi, W., Hu, Y., Nie, C., Zhou, Z. 2016. Antioxidant activity of Citrus fruits. Food Chemistry, 196:885–896.
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