A perspective review of phytochemistry and pharmacology of the Syzygium genus
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Syzygium, Phytochemistry, Bioactive Compound, Pharmacological Activity, Syndrome Metabolic
Abstract
Syzygium is a genus of the Myrtaceae family consisting of large and widespread species from Africa, Asia, Australia, and throughout Oceania and the Pacific region. Some have been cultivated for bearing fruit, ornamental plants and used as traditional medicine. This article excavated Syzygium genus which was focused on traditional uses, chemical compounds and biological activities related to treatment of syndrome metabolic. All information was obtained from the scientific literature such as Science Direct, Google Scholar, Scopus and PubMed. Several species were known to have therapeutic potential and used in traditional Chinese medicine, Ayurveda, and herbal medicine in Indonesia. Traditionally, Syzygium is known for its therapeutic purposes such as coughing, diarrhea, colds, dysentery, inflammation, pain, skin, and mouth infections. Only a few species have been scientifically studied to verify their usage as traditional medicine. There were many reports on the traditional uses and medicinal effects of Syzygium plants, but only a few review articles mainly about phytochemical constituents and their role in pharmacological activities. The present reviews highlight the phytochemical and pharmacological activity of various species of the Syzygium genus. The pharmacological activities were discussed in this article focused to metabolic syndrome treatment, such as antidiabetic, antihyperlipidemic, antioxidant and antihypertensive activities. Chemical components isolated mainly flavonoid, terpenoids/sesquiterpenoid, sterols, and lignan. Several bioactive compounds have been identified correlated with pharmacological activity, but the chemical compounds were different for each species.
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References
Adefegha, S.A., Oboh, G., Adefegha, O.M., Boligon, A.A., Athayde, M.L. 2014. Antihy perglycemic, hypolipidemic, hepatoprotective and antioxidative effects of dietary clove (Szyzgium aromaticum) bud powder in a high-fat diet/streptozotocin-induced diabetes rat model. Journal of the Science of Food and Agriculture, 94(13):2726–2737.
Alam, A.U., Howlader, M.M.R., Deen, M.J. 2013. Oxygen Plasma and Humidity Dependent Surface Analysis of Silicon, Silicon Dioxide and Glass for Direct Wafer Bonding. ECS Journal of Solid-State Science and Technology, 2(12): P515–P523.
Arumugam, B., Palanisamy, U.D., Chua, K.H., Kuppusamy, U. R. 2020. Amelioration of hyperglycemia-induced oxidative damage in ARPE-19 cells by myricetin derivatives isolated from Syzygium malaccense. Journal of Functional Foods, 67:103844.
Ayele, Y., Urga, K., Engidawork, E. 2010. Evaluation of in vivo antihypertensive and in vitro vasodepressor activities of the leaf extract of syzygium guineense (willd) D.C. Phytotherapy Research, 24(10):1457–1462.
Bai, L. Y., Lin, W. Y., Chiu, C. F., Weng, J. R. 2014. Anti-tumor Activities of Triterpenes from Syzygium kusukusense. Natural Product Communications, 9(11).
Bairy, K.L., Sharma, A., Shalini, A. 2005. Evaluation of the hypoglycemic, hypolipidemic and hepatic glycogen raising effects of Syzygium malaccense upon streptozotocin induced diabetic rats. Journal of Natural remedies, 5(1):46–51.
Barbhuiya, A., Godiya, R. 2019. Thrombolytic activity of Syzygium cumini seed extract: an in-vitro evaluation. International Journal of Pharmacy and Biological Sciences, 9(3):204–208.
Begum, S., Siddiqui, B.S., Khatoon, R., Aftab, F. 2014. Phytochemical studies on Syzygium aromaticum Linn. J. Chem. Soc. Pak, 36(3):512–516.
Bunbupha, S., Apaijit, K., Meephat, S., Maneesai, P., Prachaney, P., Pakdeechote, P. 2020. Syzygium gratum Extract Attenuates Renal Fibrosis in L- NAME Induced-Hypertensive Rats. Srinagarind Medical Journal, 35(2):135–140.
Chandran, R., Parimelazhagan, T., Shanmugam, S., Thankarajan, S. 2016. Antidiabetic activity of Syzygium calophyllifolium in Streptozotocin-Nicotinamide induced Type-2 diabetic rats. Biomedicine & Pharmacotherapy, 82:547–554.
Chumkaew, P., Kato, S., Chantrapromma, K. 2010. New cytotoxic steroids from the fruits of Syzygium siamense. Journal of Asian Natural Products Research, 12(5):424–428.
Gajera, H.P., Gevariya, S.N., Hirpara, D.G., Patel, S.V., Golakiya, B.A. 2017. Antidiabetic and antioxidant functionality associated with phenolic constituents from fruit parts of indigenous black jamun (Syzygium cumini L.) landraces. Journal of Food Science and Technology, 54(10):3180–3191.
Hu, Y.K., Wang, L., Li,Y. Y., Li,M. J., Xu, W., Zhao, Y., Li, F., Zhao, Y. 2018. Five new triterpenoids from Syzygium samarangense (Bl.) Merr. et Perry. Phytochemistry Letters, 25:147–151.
Ismail, A., Mohamed, M., Sulaiman, S.A., Ahmad, A.N. W. 2013. Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats. Evidence-Based Complementary and Alternative Medicine, 2013:1–16.
Krishnasamy, G., Muthusamy, K., Chellappan, R., Subbiah, N. 2016. Antidiabetic, anti-hyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats. Pharmaceutical Biology, 54(9):1716–1726.
Manaharan, T., Appleton, D., Cheng, H.M., Palanisamy, U.D. 2012. Flavonoids isolated from Syzygium aqueum leaf extract as potential antihyperglycaemic agents. Food Chemistry, 132(4):1802–1807.
Mudiana, D. 2016. Syzygium diversity in Gunung Baung, East Java, Indonesia. Biodiversitas Journal of Biological Diversity, 17(2):733–740.
Nahid, S., Mazumder, K., Rahman, Z., Islam, S., Rashid, M.H., Kerr, P.G. 2017. Cardio and hepato-protective potential of methanolic extract of Syzygium cumini (L.) Skeels seeds: A diabetic rat model study. Asian Pacific Journal of Tropical Biomedicine, 7(2):126–133.
Ragasa, C.Y., Torres, O.B., Shen, C.C., Lachica, M.K.G., Sulit, A.B., Chua, D.B.D.L., Ancheta, A.D.M., Ismail, C.J. B., Bernaldez, F.T.E., Raga, D. D. 2014. Triterpenes from the Leaves of Syzygium polycephalum, S. cumini, and S. samarangense. Chemistry of Natural Compounds, 50(5):942–944.
Rahim, E.N.A.A., Ismail, A., Omar, M.N., Rahmat, U.N., Ahmad, W. A.N. 2017. GC-MS Analysis of Phytochemical Compounds in Syzygium polyanthum Leaves Extracted using Ultrasound-Assisted Method. Pharmacognosy Journal, 10(1):110–119.
Ramadhania, N. R., Purnomo, A. S., Fatmawati, S. 2018. Antibacterial activities of Syzygium polyanthum wight leaves. AIP Conference Proceedings, page 020024.
Ren, Y., Anaya-Eugenio, G.D., Czarnecki, A.A., Ninh, T.N., Yuan, C., Chai, H.-B., Soejarto, D.D., Burdette, J.E., de Blanco, E.J.C., Kinghorn, A.D. 2018. Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives. Bioorganic & Medicinal Chemistry, 26(15):4452–4460.
Samy, M.N., Sugimoto, S., Matsunami, K., Otsuka, H., Kamel, M.S. 2014. One new flavonoid xyloside and one new natural triterpene rhamnoside from the leaves of Syzygium grande. Phytochemistry Letters, 10:86–90.
Shen, S.C., Chang, W.C. 2013. Hypotriglyceridemic and hypoglycemic effects of vescalagin from pink wax apple [Syzygium samarangense (Blume) Merrill and Perry cv. Pink] in high-fructose diet-induced diabetic rats. Food Chemistry, 136(2):858–863.
Sobeh, M., Petruk, G., Osman, S., Raey, M. A. E., Imbimbo, P., Monti, D. M., Wink, M. 2019. Isolation of Myricitrin and 3,5-di-O-Methyl Gossypetin from Syzygium samarangense and Evaluation of their Involvement in Protecting Keratinocytes against Oxidative Stress via Activation of the Nrf-2 Pathway. Molecules, 24(9):1839.
Tian, L.W., Xu, M., Wang, D., Zhu, H.T., Yang, C.R., Zhang, Y. J. 2011. Phenolic constituents from the leaves of Syzygium forrestii Merr. and Perry. Bio- chemical Systematics and Ecology, 39(2):156–158.
Xu, W., Tan, J., Mu, Y., Zheng, D., Huang, X., Li, L. 2020. New antimicrobial terpenoids and phloroglucinol glucosides from Syzygium szemaoense. Bioorganic Chemistry, 103.
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