Antidiabetic activity of ethanolic extract of Rhynchosia suaveolens (L.F.) DC. in Streptazotocin induced diabetic rats

Abstract

To evaluate the antidiabetic potential of ethanolic extract of Rhynchosia suaveolens (L.F.) DC. (EERS) in Streptazotocin induced diabetic rats. The Preliminary Phytochemical analysis was done by standard laboratory methods and acute toxicity studies were performed by OECD test guide lines 423. The present study, the hypoglycaemic effect of ethanolic extract of Rhynchosia suaveolens (L.F.) DC. was evaluated by using streptazotocin (STZ) induced diabetic rats at doses of 100 and 200 mg/kg p.o. daily for 28 days. The effect of extracts on diabetic rats in body weight, blood glucose, cholesterol, triglycerides, serum protein, albumin, alkaline phosphates, SGOT, SGPT, serum creatinine and urea contents were analysed. EERS shown significant (P < 0.01) reduction in blood glucose. EERS treatment significantly increase the serum protein, albumin, HDL-C, liver glycogen. EERS also significantly reduced in SGOT, SGPT, ALP, serum creatinine, urea, cholesterol, triglycerides LDL-C and AIP. Histopathology of pancreas in EERS treated group showed regeneration of β- cells. The results of the study showed that EERS exerted Posses significant antidiabetic activity in STZ induced diabetic rats which justifying its traditional use.