Lipid peroxidation and super oxide dismutase levels variation in polycystic ovarian syndrome

Abstract

Polycystic ovarian syndrome is a condition enlarged ovaries with small cysts present on the outer edges of ovary. It is a hormonal imbalance occurs in few of woman in the 18-30 years of age group. This hormonal imbalance due to poly cysts can cause the oxidative stress which aggravates the condition worse and causes other health problems. 60 subjects were selected from the outpatient department of Saveetha Dental College and Hospitals. They were separated into two groups; control group and PCOS group. 5 ml of venous blood was collected from the participants and blood was distributed in the plain collection tube and centrifuged in 2500 rpm for about 10 minutes. The Serum was isolated separately and analyzed for Malondialdehyde and Superoxide dismutase by TBARS method and Pyrogallol Autoxidation method using ERBA CHEM 5 plus analyzer. There is a significant increase in (MDA) Malondialdehyde (p<0.005) as well as there is significant decrease in (SOD) super oxide dismutase (p<0.001) in PCOS patients. Our study disclosed that there is an imbalance of antioxidant status in women having PCOS. Increased oxidative stress and decreased antioxidant capacity may bring about the increased risk of CVD in women with PCOS. Further research on oxidative stress in PCOS is needed.