Lipid peroxidation and Superoxide dismutase levels variation in Chronic Renal Failure

Abstract

Chronic Renal Failure (CRF) is a condition at which more than 50% functional loss to the renal system or kidneys. In this condition reabsorption process of nephrons will get damage which results in abnormal constituents in urine. This in terms leads to stress in the body, alters or affects different metabolisms. 40 subjects were selected from the outpatient department of Saveetha Dental College and Hospitals. They were divided into two groups. Group I (Control group) – Normal healthy individuals – 20 in numbers. Group II (Study group) – Chronic Renal failure patients (CRF) – 20 in numbers. 5ml of blood will be collected for the separation of serum. The serum was separated and analyzed for Melanaldehyde and Superoxide dismutase by TBARS method and Pyrogallol Autoxidation method using ERBA CHEM 5 plus analyzer. There is a significant increase in (MDA) lipid peroxidation (p<0.005) as well as there is a substantial decrease in (SOD) superoxide dismutase (p<0.005) in Hypothyroidism patients. Our study revealed that there is an imbalance of antioxidant status in Chronic Renal Failure (CRF) cause Cardio Vascular Diseases as well as other metabolic disorders. By estimating antioxidant status will be helpful to treat the condition before they were getting worse.