Synthesis and characterization of new imidazole azo ligand with some of transition metal ions, and their biological effect on two pathogenic bacteria of burn patients

Abstract

New imidazole azo ligand (DPIDA) was prepared by coupling reaction between 4,5-di phenyl imidazole and N1,N1-dimethylbenzene1,4-diamine di hydrochloride and studied the complexation of this ligand with Mn(II) , Co(II) , Ni(II) , Cu(II) , Zn(II) , Cd(II) , and Hg(II) ions , The free ligand and it’s complexes characterized by Mass, 1HNMR, IR, UV-Vis and molar conductivity that indicated the octahedral geometry of them with a bidentate ligand which coordinated from (N3) atom of imidazole ring and one nitrogen atom of azo group. Biological activity of ligand (DPIDA) and it's complexes tested against two multi-drug resistant aerobic pathogenic bacteria isolated from patients with a burn. Three concentrations were selected (50, 100, 150) mg/ml for each crud synthesized derivative compounds. The derivative compound (4,5-diphenyl imidazole) with concentration 150mg/ml had an excellent antibacterial effect against Staphylococcus aureus and Pseudomonas aeruginosa with inhibition zone 21.83 ± 0.1764 mm and 24.30 ± 0.4163 mm respectively.