Antioxidant effects of vitamin E on diclofenac-induced hepatotoxicity in male rats

Siva T (1) , Girija Sivakumar (2) , Sankaran PK (3) , Yuvaraj Maria Francis (4) , Gayathri T (5) , Kumaresan M (6) , Karunakaran Balaji (7)
(1) Bharath University, Chennai, Tamil Nadu, India, India ,
(2) Department of Anatomy, Karpaga Vinayaga Medical College, Mathuranthagam, Chengalpattu, Tamil Nadu, India, India ,
(3) Department of Anatomy, AIIMS, Mangalagiri, Andhra Pradesh, India, India ,
(4) Department of Anatomy, Saveetha Medical College Hospital, Thandalam, Chennai, Tamil Nadu, India, India ,
(5) Department of Anatomy, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India, India ,
(6) Department of Anatomy, Saveetha Medical College Hospital, Thandalam, Chennai, Tamil Nadu, India, India ,
(7) Department of Anatomy, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India, India

Abstract

Drug-induced liver injury possesses a major clinical problem and has become a leading cause of acute liver failure and transplantation. Overstressed liver compromises its detoxification role, which may expose it to a variety of diseases and disorders. The present study was to determine whether pre-administration of various doses of vitamin E would have a protective effect against diclofenac-induced hepatotoxicity in Wistar male rats.  Twenty-four albino male rats weighing 180-200g were divided equally into four groups. In control group rats were administrated with physiological saline 2ml/kg b.wt /intramuscularly. Another group with 50mg/kg b.wt/ intramuscularly/seven days diclofenac was used for inducing toxicity. In experimental groups, rats were administrated with different doses of vitamin E along with diclofenac sodium [200 and 400 IU orally and 50mg/kg b.wt/ intramuscularly/seven days]. Showed that there was a rapid increase in the levels of liver function test in diclofenac-treated group, which was significantly decreased after pre-treatment with high dose than low dose of vitamin E. Although the exact mechanism by with diclofenac injuries liver is not understood, some studies explain the toxicity by affecting cytochrome P 450, leading to the production of active metabolites.  Administration of different dose of diclofenac sodium induces severe adverse effects in the liver and kidney.

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Authors

Siva T
siva17187@gmail.com (Primary Contact)
Girija Sivakumar
Sankaran PK
Yuvaraj Maria Francis
Gayathri T
Kumaresan M
Karunakaran Balaji
Siva T, Girija Sivakumar, Sankaran PK, Yuvaraj Maria Francis, Gayathri T, Kumaresan M, & Karunakaran Balaji. (2019). Antioxidant effects of vitamin E on diclofenac-induced hepatotoxicity in male rats . International Journal of Research in Pharmaceutical Sciences, 10(3), 1667–1674. Retrieved from https://ijrps.com/home/article/view/3823

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