Evaluation of the gastroprotective effect of lee macrophylla

Abstract

The gastroprotective effect of Lee macrophylla was evaluated by inducing gastric ulcer by using ethanol and pylorus ligation methods, and the effect of this plant was evaluated at three doses as 100mg/kg, 200 mg/kg and 400mg/kg body weight. Due to the presence of phytoconstituents like Alkaloids, Flavonoids, Glycosides and Phenols, it was estimated that the extract could exhibit the proposed activity. The percentage of ulcer protection was 83% for Lee macrophylla and 92% for the standard. Omeprazole, the positive control included for the study also offered significant protection against ethanol-induced gastric ulcer. The Lee macrophylla of the higher dose has shown, the higher percentage of inhibition than that of the lower dose. Hence, the gastroprotective effect observed in the present study which might have been due to phytochemical such as a flavonoid, glycoside and also it is a dose-dependent activity.