Invivo Pharmacokientic and Pharamacodynamic Studies of Optimized Antihyperlipidemic Drug Loaded Solid Lipid Nanoparticle

Gannimani Veerabhadra Rao (1) , Gadela Venkata Radha (2) , Krishnaji Rao M (3) , Brito Raj S (4) , Bhaskar Reddy K (5)
(1) Department of Pharmaceutics, GITAM Institute of Pharmacy, Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India, India ,
(2) Department of Pharmaceutics, GITAM Institute of Pharmacy, Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India, India ,
(3) DIVIS Research Centre (DRC), Divis Laboratories, Sanath Nagar, Hyderabad-500018, Telangana State, India, India ,
(4) Department of Pharmaceutics, Centre for Pharmaceutical Nanotechnology, RVS Nagar, Chittoor-517127, Andhra Pradesh, India, India ,
(5) Department of Pharmaceutics, Centre for Pharmaceutical Nanotechnology, RVS Nagar, Chittoor-517127, Andhra Pradesh, India, India

Abstract

The purpose of this research is to increase bioavailability by solid lipid nanoparticle (SLN) carrier for low bioavailable drugs (< 5%) such as Lovastatin. Eight SLN loaded Lovastatin was designed and optimised by variables such as Particle Size (PS in nm) and Zeta Potential (ZP in mV) using a micro emulsification technique. SLN 7 was chosen as the optimised formulation according to the findings obtained and the same was chosen for invivo pharmacokinetic and triton-induced antihyperlipidemic operation. SLN7 confirms an improvement in bioavailability of 3.15 percent by an improvement in AUC compared to conventional dosage type (Altoprev) from the pharmacokinetic invivo results. SLN was also an appropriate career in drug delivery for Lovastatin by enhancing bioavailability and therapeutic response. The stability studies of SLN7 revealed that the evaluation parameters of SLN did not change significantly. It was verified from the data that the drug-loaded SLN was stable under varying temperature and humidity conditions. While compare to 25˚ c±2˚c/ 60% RH, SLN are more stable in 4˚ c±2˚ c and shows good reproducible reports in Particle Size (nm), Zeta potential (mV), PI and EE% data. Therefore, Solid Lipid Nanoparticle is a viable drug carrier mechanism for low bioavailable Lovastatin to improve their bioavailability through efficiently permeating them.

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Authors

Gannimani Veerabhadra Rao
gannimaniveer@gmail.com (Primary Contact)
Gadela Venkata Radha
Krishnaji Rao M
Brito Raj S
Bhaskar Reddy K
Gannimani Veerabhadra Rao, Gadela Venkata Radha, Krishnaji Rao M, Brito Raj S, & Bhaskar Reddy K. (2020). Invivo Pharmacokientic and Pharamacodynamic Studies of Optimized Antihyperlipidemic Drug Loaded Solid Lipid Nanoparticle. International Journal of Research in Pharmaceutical Sciences, 11(4), 7454–7463. Retrieved from https://ijrps.com/home/article/view/2262

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