Effect and evaluation of antihyperlipidemic activity of fractions of total methanol extract of Salvadora oleoides (decne.) leaves on Triton WR-1339 (Tyloxapol) induced hyperlipidemic rats

Deepak Kumar (1) , Versha Parcha (2) , Ishan Dhulia (3) , Alok Maithani (4)
(1) Department of Pharmaceutical Chemistry, Dolphin PG Institute of Biomedical and Natural Sciences, Manduwala, Dehradun, Uttarakhand, India, India ,
(2) Department of Pharmaceutical Sciences, Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun - 248161, Uttarakhand, India, India ,
(3) Department of Pharmaceutical Sciences, Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun - 248161, Uttarakhand, India, India ,
(4) Department of Pharmaceutical Chemistry, GRD (PG) Institute of Management and Technology, Rajpur, Dehradun, Uttarakhand, India, India

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Vol. 2 No. 3 (2011): Volume 2 Issue 3
Keywords:
    Salvadora oleoides (Decne.), Triton WR-1339, Anti-hyperlipidemic, Tyloxapol, Atherosclerosis, fenofibrate
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Abstract

Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relatively cheap and locally available. The present study focus on the anti-hyperlipidemic activity of fractions of total methanol extract of leaves of Salvadora oleoides (Decne.) against Triton WR-1339 induced hyperlipidemia in rats. Fractions administered a dose of 100mg/kg (oral) to the Triton WR-1339 induced hyperlipidemic rats. Butanol fraction showed significant reduction (p<0.05) in serum cholesterol (61.73 mg/dl), triglyceride (121.25 mg/dl), LDL (37.89 mg/dl), VLDL (24.98 mg/dl) and increase in HDL level (36.44 mg/dl) in comparison with standard drug fenofibrate (p<0.05).

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Authors

Deepak Kumar
Department of Pharmaceutical Chemistry, Dolphin PG Institute of Biomedical and Natural Sciences, Manduwala, Dehradun, Uttarakhand, India
Versha Parcha
Department of Pharmaceutical Sciences, Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun - 248161, Uttarakhand, India
vershaparcha@gmail.com (Primary Contact)
Ishan Dhulia
Department of Pharmaceutical Sciences, Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun - 248161, Uttarakhand, India
Alok Maithani
Department of Pharmaceutical Chemistry, GRD (PG) Institute of Management and Technology, Rajpur, Dehradun, Uttarakhand, India
Deepak Kumar, Versha Parcha, Ishan Dhulia, & Alok Maithani. (2011). Effect and evaluation of antihyperlipidemic activity of fractions of total methanol extract of Salvadora oleoides (decne.) leaves on Triton WR-1339 (Tyloxapol) induced hyperlipidemic rats. International Journal of Research in Pharmaceutical Sciences, 2(3), 507–510. Retrieved from https://ijrps.com/home/article/view/3203
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