Anti-ulcer activity of Mimosa pudica on Experimental animal models

Abstract

Mimosa pudica is a species belonging to the Mimosaceae family. This plant is popularly known as Touch-me-not and is widely grown as weed in tropical crops particularly when fields are hand cultivated. This species has many uses in folk medicine for example the leaf preparations were used as traditional herbal medicine for the treatment of ulcers, fever and burning sensation. The main objective of present work is to investigate the anti ulcer activity of the leaves of Mimosa pudica. The effect of aqueous and methanolic extracts of Mimosa pudicawas investigated in rats by usingtwo models, i. e. pylorus ligation and indomethacin induced ulcer models. The PH, total acidity and ulcer index were determined. The results indicated that the alcoholic extract significantly (P < 0. 001) decreases the PH, total acidity and ulcer index with respect to control at dose 400mg/kg p. o.