Uncontrolled mass use of hydroxychloroquine

Tugolbai Tagaev (1) , Sagynali Mamatov (2) , Farida Imanalieva (3) , Vityala Yethindra (4) , Altynai Zhumabekova (5) , Aizhan Bazarbaeva (6) , Yogesh Parihar (7)
(1) Department of Pathology, International Higher School of Medicine, International University of Kyrgyzstan, Bishkek-720054, Kyrgyzstan, Kyrgyzstan ,
(2) Department of Hospital Internal Medicine, Occupational Pathology with a Course of Hematology, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek-720020, Kyrgyzstan, Kyrgyzstan ,
(3) Department of Hospital Internal Medicine, Occupational Pathology with a Course of Hematology, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek-720020, Kyrgyzstan, Kyrgyzstan ,
(4) International Higher School of Medicine, International University of Kyrgyzstan, Bishkek-720054, Kyrgyzstan, Kyrgyzstan ,
(5) Gynecologist, Clinical Maternity Hospital No. 2, Bishkek-720010, Kyrgyzstan, Kyrgyzstan ,
(6) I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek-720020, Kyrgyzstan, Kyrgyzstan ,
(7) International Higher School of Medicine, International University of Kyrgyzstan, Bishkek-720054, Kyrgyzstan, Kyrgyzstan

Abstract

Hydroxychloroquine (HCQ) has previously been shown to inhibit coronavirus replication in vitro. But antiviral properties mechanisms are not well known, HCQ is a weak base that accumulates in lysosomes, modifies their pH, and interferes with some enzymes. In the lack of confirmed efficacy, the initial potential risk is not to expose patients to adverse effects. However, results from preliminary clinical studies have drawn inconclusive results regarding the efficacy of HCQ in coronavirus disease 2019 (COVID-19), due to several important weaknesses in research methodologies. Hypokalemia often occurs in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), possibly due to the particular tropism of SARS-CoV-2 with regard to Angiotensin-converting enzyme 2 (ACE2). The wide use of HCQ, even against medical advice, will show an impact on ongoing clinical trials. It is important that we can recruite COVID-19 patients in these research studies to generate appropriate data regarding drugs that show promising efficacy against COVID-19. Currently, only doctors should be allowed to prescribe HCQ, and treatment should be confined to hospital settings, with proper cardiac and therapeutic drug monitoring.

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Authors

Tugolbai Tagaev
yethindravityala10@gmail.com (Primary Contact)
Sagynali Mamatov
Farida Imanalieva
Vityala Yethindra
Altynai Zhumabekova
Aizhan Bazarbaeva
Yogesh Parihar
Tugolbai Tagaev, Sagynali Mamatov, Farida Imanalieva, Vityala Yethindra, Altynai Zhumabekova, Aizhan Bazarbaeva, & Yogesh Parihar. (2020). Uncontrolled mass use of hydroxychloroquine. International Journal of Research in Pharmaceutical Sciences, 11((SPL 1), 396–398. Retrieved from https://ijrps.com/home/article/view/1490

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