An investigation on hepatoprotective activity of entire plant of Ipomoea pestigridis (family Convolvulaceae) on hepatotoxicity induced rats

Abstract

The hepatoprotective potential of Ipomoea pestigridis  (Family Convolvulaceae) on hepatotoxicity induced rats were investigated in the present study. Ipomoea pestigridis  (Linn) (family Convolvulaceae) is “Tiger Foot Morning Glory” in English. Hepatotoxicity was induced by Paracetamol (2g/kg b.wt.) given to rats on the 5th day of the investigational period and given orally. All three extracts(PE, EA and methanol) were administered to normal and experimental hepatotoxicity rats for 7 days. Paracetamol-induced hepatotoxicity and compared with Silymarin, a standard hepatoprotective reference drug. Liver marker enzymes (ALT, ALP, AST and GGT) and Serum (Total Bilirubin, Total Protein, Total Cholesterol, Triglycerides, Albumin, Urea and Creatinine) were evaluated. Paracetamol-induced rats to exhibit elevated activities of liver enzymes such as SGOT, SGPT, ALP, gamma-glutamyl transpeptidase (GGT), creatinine, TB, urea, TC, TG and reduced total protein serum. Furthermore, Oral administration of the EA concentrates of Ipomoea pestigridis  (200 mg/ kgb.wt.) given rats were major reduction the level of SGOT, SGPT, ALP,gamma-glutamyltranspeptidase (GGT) creatinine, urea, TB, TC&TG and also significantly elevated the concentration of TB and albumin when compared to other concentrates. Thus, results suggested that EAconcentrates of Ipomoea pestigridis could afford better hepatoprotective activity against paracetamol treated hepatotoxicity rats.