Formulation and Evaluation of Taste Masking Lercanidipine Hydrochloride Oral Disintegrating Tablets
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Lercanidipine, Tulsion 339, super disintegrants, oral disintegrating tablets, disintegration time
Abstract
Lercanidipine is an antihypertensive drug. It is a dihydropyridine class of calcium channel blockers. It is extremely bitter. The reason for this exploration was to build up a non-bitter orally breaking down the tablet of inadequately solvent medication viz Lercanidipine. The bitterness of drug, masked through complexing Tulsion 339 in various ratios. Sodium starch glycolate, crospovidone, low substituted hydroxypropyl cellulose selected as super disintegrants in the formulation. The formulated tablets were assessed for various properties like Drug content, crushing strength, friability, wetting time, water retention proportion, breaking downtime and in-vitro disintegration time and dissolution studies. The disintegration time obtained in the range between 38.46-51.40 seconds. Release studies observed between 5 to 30 minutes. From the prepared formulations, formulation using Low substituted hydroxypropyl cellulose with 5% concentration showed 98.89% drug release within 30minutes. Thus, F9 was considered as best among the other formulations With effective dissolution and improves patient intake. Drug release Kinetic analysis (r2) based on best curve fitting method for optimized lercandipine formulation showed first order kinetics proves that the drug release depends upon its concentration.
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References
Kaur, M., Mittal, A., Gulati, M., Sharma, D., Kumar, R. 2020. Formulation and in vitro Evaluation of Fast Dissolving Tablets of Febuxostat Using Co Processed Excipients. Recent Patents on Drug Delivery & Formulation, 14(1):48–62.
Kuchekar, B. S., Badhan, A., Mahajan, C., S, H. 2003. Mouth dissolving tablets: A novel drug delivery system. Pharma Times, 35(7):7–9.
Liberman, L. H. A., Leon, Joseph, B., Schwartz 1987. The Theory and Practice of Industrial Pharmacy. Varghese Publishing House, Mumbai.
Mallet, L. 1996. Caring for the Elderly Patient. Journal of the American Pharmaceutical Association (1996), 36(11):628–628.
Mohanachandran, P. S., Sindhumol, P. G., Kiran, T. S. 2011. Super disintegrants: an overview. International journal of pharmaceutical sciences reviews and research, 6(1):105–114.
Pahwa, R., Gupta, N. 2011. Super disintegrants in the development of orally disintegrating tablets: a review. International journal of pharmaceutical sciences and research, 2:2767–2767.
Panigrahi, R., Behera, S. P., Panda, C. S. 2010. A Review on Fast Dissolving Tablets. Web med Central Pharmaceutical Sciences, 1(11):1–16.
Saini, S., Garg, R. 2019. Design expert assisted mathematical optimization of solubility and study of fast disintegrating tablets of Lercanidipine Hydrochloride. Journal of Drug Delivery and Therapeutics, 9(1-s):172–180.
Seager, H. 1998. Drug Delivery Products and the Zydis Fast Dissolving Dosage Form. J.Pharm. Pharmacol, 50(4):375–382.
Suresh, S., Pandit, V., Joshi, H. P. 2007. Preparation and evaluation of mouth dissolving tablets of salbutamol sulphate. Indian Journal of Pharmaceutical Sciences, 69(3):467–467.
Suryadevara, V., Lankapalli, S. R., Danda, L. H., Pendyala, V., Katta, V. 2017. Studies on jackfruit seed starch as a novel natural super disintegrant for the design and evaluation of irbesartan fast dissolving tablets. Integrative Medicine Research, 6:280–291.
Yunxia, B., Sunada, H., Yonezawa, Y., Danjo, K. 1999. Evaluation of Rapidly Disintegrating Tablets Prepared by a Direct Compression Method. Drug Development and Industrial Pharmacy, 25(5):571– 581. ISSN: 0363-9045.
Yunxia, B., Sunada, H., Yonezawa, Y., Dayo, K., Ostuka, A., Lida, K. 1996. Preparation and Evaluation of a compressed tablet rapidly disintegrating in oral cavity. Chem. Pharm bull, 44(11):2121–2127.
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