Free radical scavenging activity and cytotoxicity study of fermented oats (Avena sativa)

Veena Sunderam; Sathak Sameer Shaik Mohammed; Yasasve Madhavan; Manojj Dhinakaran; Shobana Sampath; Nirmala Patteswaran; Lakshmi Thangavelu; Ansel Vishal Lawrence

Veena Sunderam ⁽¹⁾ , Sathak Sameer Shaik Mohammed ⁽²⁾ , Yasasve Madhavan ⁽³⁾ , Manojj Dhinakaran ⁽⁴⁾ , Shobana Sampath ⁽⁵⁾ , Nirmala Patteswaran ⁽⁶⁾ , Lakshmi Thangavelu ⁽⁷⁾ , Ansel Vishal Lawrence ⁽⁸⁾

(1) Centre for Nano Science and Technology, A. C. Tech Campus, Anna University, Chennai-600025, Tamil Nadu, India, India ,

(2) Department of Biotechnology, Sree Sastha Institute of Engineering and Technology, (Affiliated to Anna University), Chennai-600123, Tamil Nadu, India, India ,

(3) Department of Biotechnology, Sree Sastha Institute of Engineering and Technology, (Affiliated to Anna University), Chennai-600123, Tamil Nadu, India, India ,

(4) Department of Biotechnology, Sree Sastha Institute of Engineering and Technology, (Affiliated to Anna University), Chennai-600123, Tamil Nadu, India, India ,

(5) Department of Biotechnology, Sree Sastha Institute of Engineering and Technology, (Affiliated to Anna University), Chennai-600123, Tamil Nadu, India, India ,

(6) Department of Biotechnology, Sree Sastha Institute of Engineering and Technology, (Affiliated to Anna University), Chennai-600123, Tamil Nadu, India, India ,

(7) Department of Pharmacology, Saveetha Dental College and Hospitals, SIMATS, Saveetha University, Chennai-600077, Tamil Nadu, India, India ,

(8) Department of Biotechnology, Sree Sastha Institute of Engineering and Technology, (Affiliated to Anna University), Chennai-600123, Tamil Nadu, India, India

Issue
Vol. 11 No. 1 (2020): Volume 11 Issue 1

Keywords:

Avena sativa, oats, In vitro studies, anti-oxidant, anti-cancer

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Abstract

Oats (Avena sativa) is a cereal crop of utmost significance with rich therapeutic and nutritive value. Bioactive substances like tocopherols, phenolic acids, alkylresorcinols, beta-glucan, and avenanthramides present in Avena sativa significantly contribute towards its medicinal action. The current research study aims to assess the antioxidant and anti-cancer efficiency of fermented (FO) and non-fermented (NFO) samples of Avena sativa. In vitro anticancer studies on oats were assessed using colon malignant growth cell lines (HT29) by MTT assay. In vitro studies revealed that fermented and non-fermented oats displayed higher antioxidant activity, having a corresponding IC₅₀ value of 201.03 µL and 236.46 µL, respectively. The cancer cell death percentage at 250 μg/mL concentration ranged between 58.19% and 51.85%, respectively.

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Authors

Veena Sunderam

Centre for Nano Science and Technology, A. C. Tech Campus, Anna University, Chennai-600025, Tamil Nadu, India

Sathak Sameer Shaik Mohammed