Tumour preventive potential of sclareol on 7, 12 dimethylbenz [a] anthracene (DMBA) induced hamster buccal pouch carcinogenesis

Abstract

Sclareol has demonstrated a broad variety of biological activities that belong to the antioxidant anti-inflammatory and anticancer activities that are used in traditional medicine. In the current study, we intended to explore the antitumor possible of sclareol along 7, 12-dimethylbenz (a) anthracene (DMBA) evoked golden Syrian hamster’s buccal pouch carcinogenesis. Lipid peroxidation and antioxidants were assessed by the buccal tissue, and plasma of DMBA evoked golden Syrian hamster buccal pouch carcinogenesis of observational animals. We observed 100% of tumor establishment and noted defects in the biochemical restrictions of lipid peroxidation and antioxidants and also histopathological observations of carcinogenesis in the hamster’s buccal pouch in DMBA only. Sclareol (20 mg/b.wt) has significantly inhibited the tumor burden, tumor volume, and increased phase II detoxification enzymes, antioxidant level, lipid peroxidation, and also phase I enzymes and has improved the histopathologically changes during carcinogenesis in the buccal pouch of  DMBA induced golden Syrian hamster. The outcomes of the present scrutinized study proposed that aiming biochemically and histopathologically that act upon the inheritance of cancer characteristics is an effectual system for chemoprevention. Therefore, our results resolved that sclareol has probably owing to its antioxidant or scavenging properties of free radical and transition act on phase I and II enzymes in regard to the evacuation of metabolites carcinogenesis, which is evoked by DMBA in hamster’s buccal pouch.