Evaluation of anti-inflammatory property of the roots of Borassus flabellifer

Abstract

Inflammation is a defense mechanism triggered by several agents and is observed as a co-morbid condition in various diseases such as cancer and diabetes. Chronic inflammation may lead to organ damage and mortality, and hence synthetic inflammatory agents are administered to cure inflammation. These synthetic drugs induce undesirable side effects, and hence natural agents are preferred. Plants have significant anti-inflammatory potential, and this study intended to assess the anti-inflammatory potential of the hydroalcoholic extract of the root of Borassus flabellifer (REBF). The evaluation was done using in-vitro models like inhibition of hemolysis and denaturation of proteins. The activity of the extract was compared with that of diclofenac, the standard drug of choice. The study results revealed that 800 μg of REBF inhibits hemolysis by 50%. The IC ₅₀ of REBF in manifesting hypotonicity induced hemolysis and heat-induced hemolysis was 2.26 mg and 820 μg. The IC5₀ of REBF required to inhibit protein denaturation was 2.1 mg. All the assay models reveal that the effect of REBF is comparable to that of diclofenac, and thus REBF is a potent anti-inflammatory agent.