Evaluation of antidiabetic potential of ethanolic extract of Caseria elliptica in streptozotocin induced diabetic rats

Abstract

The present study was focussed to evaluate the antidiabetic potential of ethanolic root extract of Caseria elliptica (CE) in Streptozotocin (STZ) induced diabetes in rats. In overnight fasted rats OGTT was performed by administration of glucose 2g/kg/p.o and the blood samples were collected periodically for glucose estimation. Diabetes was induced in rats by administration of STZ (40 mg/kg/i.p). Ethanolic root extract of CE (100mg/kg, 200mg/kg and 400mg/kg/p.o) and Glibenclamide (5mg/kg/p.o) were administered to the STZ induced diabetic rats for two weeks. Blood glucose, triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, and VLDL- cholesterol were estimated from the serum. Tissue liver glycogen content, change in body weight were estimated. The results showed that the extract dose dependently decreased the increased biochemical parameters in rats. Histopathological examinations reveals that the ethanolic extract of CE ameliorated the damaged caused to the pancreatic β-cells in STZ treated rats. From the study it was concluded that ethanolic root extract of CE possess good hypoglycemic and hypolipidemic effect.