Method Development and Validation of Ivacaftor in Bulk and Pharmaceutical dosage form by UV Spectrophotometry

Janardhana Reddy VL (1) , Raveendra Reddy P (2) , Sreenivasulu S (3)
(1) Research Scholar, Department of Chemistry, Rayalaseema University, Kurnool, 518007, Andhra Pradesh, India, India ,
(2) Department of Chemistry, S. K. University, Anantapur, 513003, Andhra Pradesh, India, India ,
(3) Department of Chemistry, Rajeev Gandhi Memorial College of Engineering and Technology, Nandhyala, Kurnool, 518502, Andhra Pradesh, India, India

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Vol. 9 No. 4 (2018): Volume 9 Issue 4
Keywords:
    Ivacaftor, Ultraviolet Spectrophotometry, Validation
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Abstract

The easiest, precise, accurate means of analysis of the drug is by UV Spectrophotometry. In this regard, Ivacaftor drug is analyzed by method development and validation for UV spectrophotometric study. The linearity studies obeyed Beer and Lambert's law where the linear regression coefficient value was found to be 0.9973 at λmax 202nm. The linearity range considered for the present study being 1-5 μg/ml. The test validation parameters and the recovery value satisfy the acceptance criteria by the method developed. Therefore the present method developed can be used for routine analysis of Bulk product and formulated dosage forms of Ivacaftor.

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Authors

Janardhana Reddy VL
Research Scholar, Department of Chemistry, Rayalaseema University, Kurnool, 518007, Andhra Pradesh, India
trivedhajanardhan@gmail.com (Primary Contact)
Raveendra Reddy P
Department of Chemistry, S. K. University, Anantapur, 513003, Andhra Pradesh, India
Sreenivasulu S
Department of Chemistry, Rajeev Gandhi Memorial College of Engineering and Technology, Nandhyala, Kurnool, 518502, Andhra Pradesh, India
Janardhana Reddy VL, Raveendra Reddy P, & Sreenivasulu S. (2018). Method Development and Validation of Ivacaftor in Bulk and Pharmaceutical dosage form by UV Spectrophotometry. International Journal of Research in Pharmaceutical Sciences, 9(4), 1048–1052. Retrieved from https://ijrps.com/home/article/view/4409
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