Method development and validation of Ceritinib in bulk and pharmaceutical dosage form by UV spectrophotometry

Janardhana Reddy VL (1) , Raveendra Reddy P (2) , Sreenivasulu S (3)
(1) Research Scholar, Department of Chemistry, Rayalaseema University, Kurnool, 518007, Andhra Pradesh, India, India ,
(2) Department of Chemistry, S. K. University, Anantapur, 513003, Andhra Pradesh, India, India ,
(3) Department of Chemistry, Rajeev Gandhi Memorial College of Engineering and Technology, Nandhyala, Kurnool, 518502, Andhra Pradesh, India, India

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Vol. 9 No. 4 (2018): Volume 9 Issue 4
Keywords:
    Ceritinib, Ultraviolet, Spectrophotometry, Validation
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Abstract

UV spectrophotometric study is the most economical method for studying and validating the drug. In this present study, a new method has been developed and validated for Ceritinib in its bulk form and its dosage form. Ceritinib showed the maximum absorbance at 206nm. The method obeyed Beer Lambert's law and the linearity concentration range was found to be 2-10 μg/ml. The results for other validation parameters were analyzed statistically and were found to fall within the acceptance criteria. The recovery studies and assay studies were found to be satisfactory.

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Authors

Janardhana Reddy VL
Research Scholar, Department of Chemistry, Rayalaseema University, Kurnool, 518007, Andhra Pradesh, India
trivedhajanardhan@gmail.com (Primary Contact)
Raveendra Reddy P
Department of Chemistry, S. K. University, Anantapur, 513003, Andhra Pradesh, India
Sreenivasulu S
Department of Chemistry, Rajeev Gandhi Memorial College of Engineering and Technology, Nandhyala, Kurnool, 518502, Andhra Pradesh, India
Janardhana Reddy VL, Raveendra Reddy P, & Sreenivasulu S. (2023). Method development and validation of Ceritinib in bulk and pharmaceutical dosage form by UV spectrophotometry. International Journal of Research in Pharmaceutical Sciences, 9(4), 1020–1024. Retrieved from https://ijrps.com/home/article/view/4405
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