Correlation between ABO blood groups with insulin resistance in type II diabetes mellitus patients using Metformin

Haithem R. Mohammed (1) , Kadhim A. Kadhim (2) , Hasan Murtadha Alkutubi (3) , Abbas M. Rahmah (4) , Ban H. Khalaf (5) , Saad Abdal-Rahman Hussein (6) , Hayder Adnan Fawzi (7)
(1) Department Clinical Pharmacy, College of Pharmacy, University of Karbala, Karbala, Iraq , Iraq ,
(2) Department Clinical Pharmacy, College of Pharmacy, University of Al- Mustansiriya, Baghdad, Iraq , Iraq ,
(3) CABMS, Al-Hussein Medical City, Karbala, Iraq, Iraq ,
(4) Director of the National Diabetes Centre, University of Al-Mustansiriyah, Baghdad, Iraq , Iraq ,
(5) Department of Pharmacology and Toxicology, Karbala University, Karbala, Iraq , Iraq ,
(6) Department of Pharmacology and Toxicology, Al-Rafedin university, Baghdad, Iraq , Iraq ,
(7) Baghdad Teaching Hospital, Department of Clinical Pharmacy, Baghdad, Iraq, Iraq

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Vol. 9 No. 3 (2018): Volume 9 Issue 3
Keywords:
    ABO blood, Glycaemic control, Insulin resistance
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Abstract

The aim of the present study to investigate the relationship between ABO blood group with glycaemic control and insulin resistance in type II DM using metformin therapy. Fifty-five patients newly diagnosed with type 2 diabetes mellitus collected in diabetic centre Al-Husseini hospital by the specialist physician according to the American Association of Diabetes, from December 2015 to May 2016. ABO blood group based on insulin resistance, blood glucose and body mass index were determined and correlated with each other. AB blood group had more reduction in FBG, HbA1c %, BMI (-38.6,-.22.8,-55.1, -4.3, respectively) by effect metformin treatment after three months from other blood groups. Correlation of ABO blood groups based on insulin resistance with FBG and HbA1c% showed AB blood group had more reduction in glycemic control (FBG, HbA1c %) after metformin treatment. The present study showed that different ABO blood groups had a different effect on glycemic control and insulin resistance about metformin treatment in newly diagnosed type 2 diabetes after three months. Also, AB blood group more association with response metformin treatment compared with other blood groups.

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Authors

Haithem R. Mohammed
Department Clinical Pharmacy, College of Pharmacy, University of Karbala, Karbala, Iraq
Kadhim A. Kadhim
Department Clinical Pharmacy, College of Pharmacy, University of Al- Mustansiriya, Baghdad, Iraq
Hasan Murtadha Alkutubi
CABMS, Al-Hussein Medical City, Karbala, Iraq
Abbas M. Rahmah
Director of the National Diabetes Centre, University of Al-Mustansiriyah, Baghdad, Iraq
Ban H. Khalaf
Department of Pharmacology and Toxicology, Karbala University, Karbala, Iraq
Saad Abdal-Rahman Hussein
Department of Pharmacology and Toxicology, Al-Rafedin university, Baghdad, Iraq
Hayder Adnan Fawzi
Baghdad Teaching Hospital, Department of Clinical Pharmacy, Baghdad, Iraq
hayder.adnan2010@ierit.nahrainuniv.edu.iq (Primary Contact)
Haithem R. Mohammed, Kadhim A. Kadhim, Hasan Murtadha Alkutubi, Abbas M. Rahmah, Ban H. Khalaf, Saad Abdal-Rahman Hussein, & Hayder Adnan Fawzi. (2018). Correlation between ABO blood groups with insulin resistance in type II diabetes mellitus patients using Metformin. International Journal of Research in Pharmaceutical Sciences, 9(3), 749–756. Retrieved from https://ijrps.com/home/article/view/4341
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