Design and evaluation of Oxiconazole based ethosome for novel drug delivery to the skin

Abstract

Last few decades the act of regular drug for the wound healing improving in many parts of India depends on the sources such as herbal, semi-synthetic and synthetic medicines. Despite the fact that the pharmaceutical innovation currently has focused on the improvement of nano drug delivery systems such as liposomes, niosomes, nanosomes, ethosomes, dendrimers, nanoparticle etc. This could be a novel approach towards skin mediated drug delivery system. An attempt was made to formulate highly effectual oxiconazole gel. In this current work oxiconazole, loaded ethosomes were formulated in the form of a gel for the treatment for the skin infection. The preformulation study confirms low interparticle friction between the drug and polymers with better flow property. FTIR and DSC analysis confirm that there is no prominent chemical reaction between oxiconazole and polymers. Ethosomes has been prepared by using the injection method by introducing semi-synthetic and natural polymers. The prepared ethosomes are in the range of micrometre and found as spherical confirmed by TEM and SEM analysis. The smaller size of the particle and polyethene glycol plays an important role to enhance the skin penetration. Evaluation study (such as drug entrapment efficiency, percentage yield, drug content, pH, viscosity and spreadability) for ethosomes has been carried out and found optimum as per the IP. Formulation E16 has shown a better result in sustaining the oxiconazole as 93% in 12h. The kinetic release study follows non-fickian behaviour.