Mucoadhesive targeted pulmonary delivery of nanoparticulated dry powder insufflators-A revolt in TB therapy

Abstract

The emergence of multidrug-resistant TB (MDR-TB) against first-line drugs and extensively drug resistant TB (XDR- TB) due to misuse of second-line anti tubercular drugs (ATDs) is a further concern. Recommended treatment in- volves long term and multiple drug therapy with severe side effects. Due to this concern nanoparticle-based sys- tems have significant potential for treatment and prevention of tuberculosis (TB) to overcome the need to administer ATDs at high and frequent doses, would assist in improving patient compliance and circumvent hepatotoxicity and/or nephrotoxicity/ocular toxicity/ototoxicity associated with the prevalent first-line chemotherapy. Nanostructured delivery systems constitute a wide range of systems varying from liposomes, micelles, micro- and nanoemulsions, to polymeric nanoparticles (PNPs) and solid lipid nanoparticles (SLNs). Pulmonary administration of inhaled nanoparticles in the form of dry powder inhalers offer particular advantages for pulmonary administration of anti tubercular drugs (ATDs). Present review comprehensively about different approaches of nanobased drug delivery, devises and techniques for pulmonary delivery of nanoparticle encapsulated ATD.