Effects of Riluzole on Nr2B subunits of NMDA receptors in rat migraine model

Sankaran PK (1) , Gunapriya Raghunath (2) , Joy Ghoshal (3) , Yuvaraj Maria Francis (4) , Siva T (5) , Kumaresan M (6) , Karthikeyan (7) , Nandha Kumar (8)
(1) Research Scholar, Bharath University, Chennai, Tamil Nadu, India, India ,
(2) Department of Anatomy, Saveetha Institute of Medical and Technical Sciences (Deemed University), Thandalam, Chennai-602 105, Tamil Nadu, India, India ,
(3) Department of Anatomy, AIIMS, Mangalagiri-52008, Andhra Pradesh, India, India ,
(4) Department of Anatomy, Saveetha Institute of Medical and Technical Sciences (Deemed University), Thandalam, Chennai-602 105, Tamil Nadu, India, India ,
(5) Department of Anatomy, Sri Ramachandra Medical College & Research Institute, Porur, Chennai, Tamil Nadu, India, India ,
(6) Department of Anatomy, Saveetha Institute of Medical and Technical Sciences (Deemed University), Thandalam, Chennai-602 105, Tamil Nadu, India, India ,
(7) Department of Anatomy, Saveetha Institute of Medical and Technical Sciences (Deemed University), Thandalam, Chennai-602 105, Tamil Nadu, India, India ,
(8) Department of Anatomy, AIIMS, Mangalagiri-52008, Andhra Pradesh, India, India

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Issue
Vol. 10 No. 3 (2019): Volume 10 Issue 3
Keywords:
    Migraine, Riluzole, Glutamate, Headache, NMDA
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Abstract

Migraine, a major public health problem, occurring due to the consequences of serial multi-pathophysiological changes in the trigeminal nerve ganglion leading to an imbalance in the excitation and inhibition. The glutamate is the major excitatory neurotransmitter in the central nervous system, causing excitotoxicity to the sensory neurons leading to sensitization and nociception. The present study was done to determine the effects of Riluzole on the Nr2B subunits of NMDA receptors after inducing a migraine. The rats were treated with Riluzole after inducing migraine with nitroglycerin 10mg/kg. The nitroglycerin treated rats showed intense staining for NR2B subunits, and there was a decrease in the expression after Riluzole treatment. This study concludes that the NR2B subunits are upregulated during migraine and Riluzole can be used to control those upregulations by its neuroprotectant property.

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Authors

Sankaran PK
Research Scholar, Bharath University, Chennai, Tamil Nadu, India
brightcareres@gmail.com (Primary Contact)
Gunapriya Raghunath
Department of Anatomy, Saveetha Institute of Medical and Technical Sciences (Deemed University), Thandalam, Chennai-602 105, Tamil Nadu, India
Joy Ghoshal
Department of Anatomy, AIIMS, Mangalagiri-52008, Andhra Pradesh, India
Yuvaraj Maria Francis
Department of Anatomy, Saveetha Institute of Medical and Technical Sciences (Deemed University), Thandalam, Chennai-602 105, Tamil Nadu, India
Siva T
Department of Anatomy, Sri Ramachandra Medical College & Research Institute, Porur, Chennai, Tamil Nadu, India
Kumaresan M
Department of Anatomy, Saveetha Institute of Medical and Technical Sciences (Deemed University), Thandalam, Chennai-602 105, Tamil Nadu, India
Karthikeyan
Department of Anatomy, Saveetha Institute of Medical and Technical Sciences (Deemed University), Thandalam, Chennai-602 105, Tamil Nadu, India
Nandha Kumar
Department of Anatomy, AIIMS, Mangalagiri-52008, Andhra Pradesh, India
Sankaran PK, Gunapriya Raghunath, Joy Ghoshal, Yuvaraj Maria Francis, Siva T, Kumaresan M, Karthikeyan, & Nandha Kumar. (2019). Effects of Riluzole on Nr2B subunits of NMDA receptors in rat migraine model. International Journal of Research in Pharmaceutical Sciences, 10(3), 2242–2245. Retrieved from https://ijrps.com/home/article/view/4061
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