Selection of excipients for the formulation of Ceftriaxone sodium loaded chitosan Nanoparticle through drug - excipient compatibility testing

Abstract

Ceftriaxone (CFTX) sodium is a 3rd generation semisynthetic antibiotic that can effectively treat several types of bacterial infections. The best formulation is considered appropriate when no interactions between drug-excipient or excipient-excipient occur. To obtain the best formulation preformulation study is an essential tool and desiring a quick and accurate method to evaluate and choose the best excipients for stable dosage forms. The aim of the present work was to study the compatibility of Ceftriaxone sodium drug substance with the excipients employed in colon target release capsule preformulation by testing the Thermo gravimetric analysis (TGA) study and Fourier transform the Infrared spectrophotometric study (FTIR). Based on the TGA results Ceftriaxone was found to be compatible with Chitosan and Sodium Tri polyphosphate. FTIR was used as supportive techniques for the analysis.