Investigation of hypoglycemic and hypolipidemic activity of ethanolic extract of Grewia serrulata DC on high fat diet (HFD) - streptozotocin (STZ) induced diabetic rats

Abstract

The present study was aimed to investigate the antihyperglcemic activity of ethanolic extract of aerial parts of Grewia Serrulata DC (EEGS) on high fat diet (HFD) - streptozotocin (STZ) induced diabetic rats. Male wistar albino rats were fed with a high fat diet for a period of two weeks prior to the administration of streptozotocin (50mg/kg) intraperitonially. The long term effect of the extract was studied by treating diabetic rats with vehicle (0.5% CMC) and EEGS (200 and 400 mg/kg b wt) for a period of 28 days. The effects of EEGS on fasting blood glucose and serum insulin levels were studied. In addition, body weight changes, lipid profile and serum biomarkers of liver and kidney function were also studied. Results revealed that EEGS-400mg shows excellent antihyperglycemic activity when compared to lower dose of the extract 200mg and also shows better antihyperlipidemic activity. The elevated serum urea and creatinine levels also decreased by the treatment with extract. Hence the results justify that Grewia serrulata DC possess antidiabetic activity.