Abstract
The present study addresses the synthesis of 1,2-dienes from terminal alkynes, during the rearrangement process in the presence of Cu (I) Catalyst. Terminal alkynes were prepared by using aldehyde or ketone in the presence of sodium actylide and allenes formed under mild conditions. The structures of synthesized compounds were confirmed by using TLC, FT-IR, 1H-NMR and mass spectroscopic techniques. The synthesized 1,2-dienes were screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus. The antibacterial analysis shows that compound 2f scored good activity compared to the all other synthesized compounds. Besides, the compounds 1- (4-chlorobuta-2,3-dien-2-yl)benzene (2b) and (2e) also shows moderate antibacterial activity.
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