A stability indicating RP-HPLC method for simultaneous estimation of Emtricitabine, Tenofovir disoproxil fumarate and Efavirenz in pharmaceutical dosage forms

Sreekanth Nadig (1) , Jane T Jacob (2) , Ishwar Bhat (3) , Kishoreraju V. (4)
(1) Department of Pharmaceutical Chemistry, Nitte Gulbishetty Institue of Pharmaceutical Sciences, Mangalore, Karnataka, India, India ,
(2) Department of Pharmaceutical Chemistry, Nitte Gulbishetty Institue of Pharmaceutical Sciences, Mangalore, Karnataka, India, India ,
(3) Department of Pharmaceutical Chemistry, Nitte Gulbishetty Institue of Pharmaceutical Sciences, Mangalore, Karnataka, India, India ,
(4) Novel Laboratories Inc, Somerset, New Jersey, USA, United States

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Vol. 4 No. 3 (2013): Volume 4 Issue 3
Keywords:
    Emtricitabine, Tenofovir disoproxil fumarate, Efavirenz, HPLC, Validation
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Abstract

A stability indicating RP-HPLC method has been developed for quantitative determination of Emtricitabine, Tenofovir Disoproxil Fumarate and Efavirenz in Pharmaceutical dosage forms. Chromatographic separation was achieved through gradient elution. Detection wavelength was monitored at 262 nm. The retention times of the Emtricitibine, Tenofovir disoproxil fumarate and Efavirenz was about 2.6, 5.4, 7.9min respectively. The developed method was validated as per ICH guidelines. This method is found to be simple, fast and economical Hence this validated method can be used in routine quality testing of individual dosage forms and combination dosage forms of Emtricitabine, Tenofovir disoproxil fumarate and Efavirenz.

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Authors

Sreekanth Nadig
Department of Pharmaceutical Chemistry, Nitte Gulbishetty Institue of Pharmaceutical Sciences, Mangalore, Karnataka, India
sreekanth30@rediffmail.com (Primary Contact)
Jane T Jacob
Department of Pharmaceutical Chemistry, Nitte Gulbishetty Institue of Pharmaceutical Sciences, Mangalore, Karnataka, India
Ishwar Bhat
Department of Pharmaceutical Chemistry, Nitte Gulbishetty Institue of Pharmaceutical Sciences, Mangalore, Karnataka, India
Kishoreraju V.
Novel Laboratories Inc, Somerset, New Jersey, USA
Sreekanth Nadig, Jane T Jacob, Ishwar Bhat, & Kishoreraju V. (2013). A stability indicating RP-HPLC method for simultaneous estimation of Emtricitabine, Tenofovir disoproxil fumarate and Efavirenz in pharmaceutical dosage forms. International Journal of Research in Pharmaceutical Sciences, 4(3), 391–396. Retrieved from https://ijrps.com/home/article/view/3726
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