Formulation and physicochemical evaluation of Indomethacin transdermal patches

Venkatachalam V.V. (1) ,  Ravichandran S. (2) , Subramanian S. (3) , Andhuvan G. (4)
(1) Department of Pharmacy, Annamalai University, Annamalainagar, Tamil Nadu, India, India ,
(2) Department of Pharmaceutical Analysis, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India, India ,
(3) Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India, India ,
(4) Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India, India

Abstract

Indomethacin is a NSAID available for several decades, highly effective against any condition of pain. In this study drug dispersion with different polymers like hydroxyl propyl methyl cellulose (HPMC), polyvinyl pyrolidine (PVP), ethyl cellulose(EC), either in individual or combination were used, with or without rate controlling membrane of 1%W/V of ethyl cellulose to formulate matrix type of transdrmal patches. All the patches were prepared by added 20%W/V of di butyl phthalate (DBP) as plasticizer to make the film flexible and free from brittleness and the solvent used for dispersion was ethanol as common solvent. The prepared patches were evaluated for various physico-chemical parameters like film thickness, film weight variation, folding endurance, water absorption capacity, percentage moisture loss, percentage moisture absorption, weight vapor transmission rate, tensile strength & percentage elongation and drug content uniformity.

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Authors

Venkatachalam V.V.
subbu3j@gmail.com (Primary Contact)
 Ravichandran S.
Subramanian S.
Andhuvan G.
Venkatachalam V.V.,  Ravichandran S., Subramanian S., & Andhuvan G. (2012). Formulation and physicochemical evaluation of Indomethacin transdermal patches. International Journal of Research in Pharmaceutical Sciences, 3(2), 356–359. Retrieved from https://ijrps.com/home/article/view/3680

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