Formulation and physicochemical evaluation of Indomethacin transdermal patches

Abstract

Indomethacin is a NSAID available for several decades, highly effective against any condition of pain. In this study drug dispersion with different polymers like hydroxyl propyl methyl cellulose (HPMC), polyvinyl pyrolidine (PVP), ethyl cellulose(EC), either in individual or combination were used, with or without rate controlling membrane of 1%W/V of ethyl cellulose to formulate matrix type of transdrmal patches. All the patches were prepared by added 20%W/V of di butyl phthalate (DBP) as plasticizer to make the film flexible and free from brittleness and the solvent used for dispersion was ethanol as common solvent. The prepared patches were evaluated for various physico-chemical parameters like film thickness, film weight variation, folding endurance, water absorption capacity, percentage moisture loss, percentage moisture absorption, weight vapor transmission rate, tensile strength & percentage elongation and drug content uniformity.