The cellular genetics effect of pyrethroid on lab rabbits

Abstract

The mutagenicity and genotoxicity of sumicidin insecticide 30 EC, which is classified as a synthetic pyrethroid w 30 studied using mitotic index (MI) and chromosomal aberration (CA) in somatic cells (bone marrow and spleen) and male germ cells of rabbits. Sumicidin was administered orally at dose level (2 X 10^-5, 2.5 X 10^-5, 3 X 10^-5M) and control dose level of mitomycin C. Result show that high doses of sumicidin cause a significant reduction in MI and a significant increase in CA for all tissues. Reduction in MI level was significantly higher (p<0.01) in bone marrow and male germ cells than spleen while there is a significant increase in CA level in male germ cells, compared with somatic cells. These results indicate that sumicidin 30 EC is potentially genotoxic in rabbits.