Anti inflammatory activity of Parkinsonia acculeata on carrageenan and formalin induced rat paw edema in rats

Ghalib I. Hundekari; Shukoor M. A; Nagappa A. N; Syeda Shahana; Syeda Saba; Shaikh Samina

Ghalib I. Hundekari ⁽¹⁾ , Shukoor M. A ⁽²⁾ , Nagappa A. N ⁽³⁾ , Syeda Shahana ⁽⁴⁾ , Syeda Saba ⁽⁵⁾ , Shaikh Samina ⁽⁶⁾

(1) Kamala Nehru Polytechnic Pharmacy, Aurangabad 431001, India, India ,

(2) Kamala Nehru Polytechnic Pharmacy, Aurangabad 431001, India, India ,

(3) Kamala Nehru Polytechnic Pharmacy, Aurangabad 431001, India, India ,

(4) Y. B. Chavan College of Pharmacy Aurangabad, India, India ,

(5) Kamala Nehru Polytechnic Pharmacy, Aurangabad 431001, India, India ,

(6) Kamala Nehru Polytechnic Pharmacy, Aurangabad 431001, India, India

Issue
Vol. 3 No. 3 (2012): Volume 3 Issue 3

Keywords:

Parkinsonia acculeata, Carrageenan, formalin, anti-inflammatory

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Abstract

The anti-inflammatory effect of the Pet ether and aqueous leaf extract of Parkinsonia acculeata was evaluated using the carrageenan and formalin induced rat paw edema. The extract administered orally at 500 mg/kg b. w produced a significant inhibition. The results obtained suggest that the Pet ether and aqueous leaf extract of Par- kinsonia acculeata is endowed with effective anti-inflammatory activity mediated via either inhibition of cyclo- oxygenase pathways, inhibiting the synthesis of inflammatory mediators and scavenging free oxygen radicals. These findings seem to justify that the plant can be used as an anti-inflammatory agent.