Development and evaluation of medicated soap strip’s of clotrimazole for dermal infection

Abstract

The research is aimed to formulate clotrimazole paper soap strip that will result in faster drug release through foam; for better and effective relief from fungal infections like tinea, cutaneous candidiasis and seborrhoeic dermatitis. The formulation of medicated paper soap strips was carried out in two phases. Phase-I optimization Study, consist of formulation of non medicated paper soap strip; by randomly selecting marketed soap bars, then preparing their soap solution of varying concentration and then different pharmaceutical grade papers were dipped into these soap solution and air dried. The formulated soap strips were then evaluated for soap absorption capacity on paper, weight gain, thickness, size, shape, foam, and stability studies. From the results best soap, its soap solution concentration and paper was screened out. Phase-II study involves incorporation of drug into the best soap and its soap solution was achieved by emulsification technique and application of medicated soap solution over best paper was achieved by dipping technique. Medicated paper soap strip were characterized for thickness, weight, foam test, stability studies, drug content uniformity, FTIR, in vitro drug release studies carried out in 0.1N HCl media showed 40.17% drug release in 30 min. The primary skin irritation studies carried out on guinea pigs, showed no sensitization and edema on skin after 72 hours of application. Zone of inhibition has revealed the potential antimicrobial activity the drug formulation. The results of present study revealed that the prepared medicated paper soap strips of Clotrimazole is economic, convenient, gives good foam on application, uniform drug content and no skin irritation on animals.